靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T90648

FORMERID

TTDR01373

UNIPROID

BRAF_HUMAN

TARGNAME

B-Raf messenger RNA (BRAF mRNA)

GENENAME

BRAF

TARGTYPE

Clinical trial target

SYNONYMS

V-Raf murine sarcoma viral oncogene homolog B1 (mRNA); Serine/threonine-protein kinase B-raf (mRNA); RAFB1 (mRNA); Proto-oncogene B-Raf (mRNA); P94 (mRNA); BRAF1 (mRNA); BRAF(V599E) (mRNA); BRAF serine/threonine kinase (mRNA); B-raf protein (mRNA); B-Raf (mRNA)

FUNCTION

May play a role in the postsynaptic responses of hippocampal neuron. Phosphorylates MAP2K1, and thereby contributes to the MAP kinase signal transduction pathway. Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus.

PDBSTRUC

6CAD; 6B8U; 5VYK; 5VR3; 5VAM

BIOCLASS

mRNA target

ECNUMBER

EC 2.7.11.1

SEQUENCE

MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH

DRUGINFO

MLN2480

DRUGINFO

PLX-4720

DRUGINFO

RG7304

DRUGINFO

SPN-803

DRUGINFO

2-(Benzylamino)-6-(3-acetamidophenyl)pyrazine

Investigative

DRUGINFO

D01DDB

2-(Phenylamino)-6-(3-acetamidophenyl)pyrazine

DRUGINFO

ISIS 13727

DRUGINFO

ISIS 13730

目标的 KEGG 通路数据

标题	内容
hsa04010	MAPK signaling pathway
hsa04012	ErbB signaling pathway
hsa04015	Rap1 signaling pathway
hsa04024	cAMP signaling pathway
hsa04062	Chemokine signaling pathway
hsa04068	FoxO signaling pathway
hsa04150	mTOR signaling pathway
hsa04270	Vascular smooth muscle contraction
hsa04510	Focal adhesion
hsa04650	Natural killer cell mediated cytotoxicity
hsa04720	Long-term potentiation
hsa04722	Neurotrophin signaling pathway
hsa04726	Serotonergic synapse
hsa04730	Long-term depression
hsa04810	Regulation of actin cytoskeleton
hsa04910	Insulin signaling pathway
hsa04914	Progesterone-mediated oocyte maturation
hsa05034	Alcoholism
hsa05160	Hepatitis C
hsa05200	Pathways in cancer
hsa05205	Proteoglycans in cancer
hsa05210	Colorectal cancer
hsa05211	Renal cell carcinoma
hsa05212	Pancreatic cancer
hsa05213	Endometrial cancer
hsa05214	Glioma
hsa05215	Prostate cancer
hsa05216	Thyroid cancer
hsa05218	Melanoma
hsa05219	Bladder cancer
hsa05220	Chronic myeloid leukemia
hsa05221	Acute myeloid leukemia
hsa05223	Non-small cell lung cancer

目标的 Wiki 路径数据

标题	内容
WP734	Serotonin Receptor 4/6/7 and NR3C Signaling
WP722	Serotonin HTR1 Group and FOS Pathway
WP615	Senescence and Autophagy in Cancer
WP51	Regulation of Actin Cytoskeleton
WP437	EGF/EGFR Signaling Pathway
WP422	MAPK Cascade
WP382	MAPK Signaling Pathway
WP2828	Bladder Cancer
WP2754	Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
WP2571	Polycystic Kidney Disease Pathway
WP2355	Corticotropin-releasing hormone
WP23	B Cell Receptor Signaling Pathway
WP2261	Signaling Pathways in Glioblastoma
WP1984	Integrated Breast Cancer Pathway
WP1911	Signaling by FGFR
WP1873	NGF signalling via TRKA from the plasma membrane
WP185	Integrin-mediated Cell Adhesion

目标的蛋白质ID

标题	内容
TARGETID	T90648
UNIPROID	BRAF_HUMAN
TARGNAME	B-Raf messenger RNA (BRAF mRNA)
TARGTYPE	Clinical Trial target

目标的序列数据

标题	内容
B-Raf messenger RNA (BRAF mRNA)	MAALSGGGGGGAEPGQALFNGDMEPEAGAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLGNGTDFSVSSSASMDTVTSSSSSSLSVLPSSLSVFQNPTDVARSNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPIPQEEASLAETALTSGSSPSAPASDSIGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSEDRNRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGAFPVH

标题

内容

B-Raf messenger RNA (BRAF mRNA)

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