TARGETID

T89529

FORMERID

TTDR01437

UNIPROID

PTN1_HUMAN

TARGNAME

PTPN1 messenger RNA (PTPN1 mRNA)

GENENAME

PTPN1

TARGTYPE

Successful target

SYNONYMS

Tyrosine-protein phosphatase non-receptor type 1 (mRNA); PTP-1B (mRNA)

FUNCTION

Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response.

PDBSTRUC

6CWV; 6CWU; 6BAI; 6B95; 6B90

BIOCLASS

mRNA target

ECNUMBER

EC 3.1.3.48

SEQUENCE

MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLTAGAYLCYRFLFNSNT

DRUGINFO

Hydrogen peroxide

DRUGINFO

TRYPAN BLUE

DRUGINFO

ISIS 113715

DRUGINFO

ISIS-PTP1Brx

DRUGINFO

URSOLIC ACID

DRUGINFO

ERTIPROTAFIB

DRUGINFO

[[4-(Aminomethyl)Phenyl]Amino]Oxo-Acetic Acid,

DRUGINFO

1,2,3,4,6-penta-O-galloyl-D-glucopyranose