TARGETID

T89041

FORMERID

TTDS00241

UNIPROID

CP17A_HUMAN

TARGNAME

Steroid 17-alpha-monooxygenase (S17AH)

GENENAME

CYP17A1

TARGTYPE

Successful target

SYNONYMS

Steroid 17-alpha-hydroxylase/17,20 lyase; P450c17; P450-C17; P450 17; CYPXVII; CYP17A1; CYP 17; 17 alpha-Hydroxylase/C17-20-lyase

FUNCTION

Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.

PDBSTRUC

6CIZ; 6CIR; 6CHI; 5UYS; 5IRV

BIOCLASS

Paired donor oxygen oxidoreductase

ECNUMBER

EC 1.14.14.19

SEQUENCE

MWELVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVRQAWREAQAEGST

DRUGINFO

ABIRATERONE

DRUGINFO

Abiraterone acetate

DRUGINFO

TAK-700

DRUGINFO

Seviteronel

DRUGINFO

CFG920

DRUGINFO

DST-2970

DRUGINFO

1-((9H-Fluoren-2-yl)ethyl)-1H-imidazole

DRUGINFO

1-((9H-Fluoren-2-yl)methyl)-1H-imidazole