TARGETID

T88729

FORMERID

TTDR00082

UNIPROID

UCP1_HUMAN

TARGNAME

Mitochondrial uncoupling protein 1 (UCP1)

GENENAME

UCP1

TARGTYPE

Clinical trial target

SYNONYMS

UCP 1; UCP; Thermogenin; Solute carrier family 25 member 7; SLC25A7; Mitochondrial brown fat uncoupling protein 1

FUNCTION

Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria. Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates to non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance.

BIOCLASS

Mitochondrial carrier

SEQUENCE

MGGLTASDVHPTLGVQLFSAGIAACLADVITFPLDTAKVRLQVQGECPTSSVIRYKGVLGTITAVVKTEGRMKLYSGLPAGLQRQISSASLRIGLYDTVQEFLTAGKETAPSLGSKILAGLTTGGVAVFIGQPTEVVKVRLQAQSHLHGIKPRYTGTYNAYRIIATTEGLTGLWKGTTPNLMRSVIINCTELVTYDLMKEAFVKNNILADDVPCHLVSALIAGFCATAMSSPVDVVKTRFINSPPGQYKSVPNCAMKVFTNEGPTAFFKGLVPSFLRLGSWNVIMFVCFEQLKRELSKSRQTMDCAT

DRUGINFO

CL-316,243

DRUGINFO

NC-2100

KEGGPATH

hsa03320:PPAR signaling pathway

KEGGPATH

hsa05016:Huntington's disease

WIKIPATH

WP111:Electron Transport Chain

WIKIPATH

WP1902:Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

WIKIPATH

WP236:Adipogenesis