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靶点信息38(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Lactoylglutathione lyase (GLO1)
TARGTYPE
Clinical trial target
SYNONYMS
S-D-lactoylglutathione methylglyoxal lyase; Methylglyoxalase; Ketone-aldehyde mutase; Glyoxalase I; GlxI; Glx I; GLO1; Aldoketomutase
FUNCTION
Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF- kappa-B. Required for normal osteoclastogenesis.
PDBSTRUC
3W0U; 3W0T; 3VW9; 1QIP; 1QIN
BIOCLASS
Carbon-sulfur lyases
SEQUENCE
MAEPQPPSGGLTDEAALSCCSDADPSTKDFLLQQTMLRVKDPKKSLDFYTRVLGMTLIQKCDFPIMKFSLYFLAYEDKNDIPKEKDEKIAWALSRKATLELTHNWGTEDDETQSYHNGNSDPRGFGHIGIAVPDVYSACKRFEELGVKFVKKPDDGKMKGLAFIQDPDGYWIEILNPNKMATLM
DRUGINFO
2-Sulfhydryl-Ethanol
DRUGINFO
PELARGONIDIN CHLORIDE
DRUGINFO
S-(N-4bromophenyl-N-hydroxycarbamoyl)glutathione
DRUGINFO
S-(N-4chlorophenyl-N-hydroxycarbamoyl)glutathione
目标的蛋白质ID
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目标的序列数据
| 标题 | 内容 |
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| Lactoylglutathione lyase (GLO1) |
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