靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T88182

FORMERID

TTDS00486

UNIPROID

VKGC_HUMAN

TARGNAME

Vitamin K-dependent gamma-carboxylase (GGCX)

GENENAME

GGCX

TARGTYPE

Successful target

SYNONYMS

Vitamin K gamma glutamyl carboxylase; Gamma-glutamyl carboxylase; GGCX

FUNCTION

Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide.

BIOCLASS

Carbon-carbon lyase

ECNUMBER

EC 4.1.1.90

SEQUENCE

MAVSAGSARTSPSSDKVQKDKAELISGPRQDSRIGKLLGFEWTDLSSWRRLVTLLNRPTDPASLAVFRFLFGFLMVLDIPQERGLSSLDRKYLDGLDVCRFPLLDALRPLPLDWMYLVYTIMFLGALGMMLGLCYRISCVLFLLPYWYVFLLDKTSWNNHSYLYGLLAFQLTFMDANHYWSVDGLLNAHRRNAHVPLWNYAVLRGQIFIVYFIAGVKKLDADWVEGYSMEYLSRHWLFSPFKLLLSEELTSLLVVHWGGLLLDLSAGFLLFFDVSRSIGLFFVSYFHCMNSQLFSIGMFSYVMLASSPLFCSPEWPRKLVSYCPRRLQQLLPLKAAPQPSVSCVYKRSRGKSGQKPGLRHQLGAAFTLLYLLEQLFLPYSHFLTQGYNNWTNGLYGYSWDMMVHSRSHQHVKITYRDGRTGELGYLNPGVFTQSRRWKDHADMLKQYATCLSRLLPKYNVTEPQIYFDIWVSINDRFQQRIFDPRVDIVQAAWSPFQRTSWVQPLLMDLSPWRAKLQEIKSSLDNHTEVVFIADFPGLHLENFVSEDLGNTSIQLLQGEVTVELVAEQKNQTLREGEKMQLPAGEYHKVYTTSPSPSCYMYVYVNTTELALEQDLAYLQELKEKVENGSETGPLPPELQPLLEGEVKGGPEPTPLVQTFLRRQQRLQEIERRRNTPFHERFFRFLLRKLYVFRRSFLMTCISLRNLILGRPSLEQLAQEVTYANLRPFEAVGELNPSNTDSSHSNPPESNPDPVHSEF

DRUGINFO

D00FSV

Phytonadione

Approved

KEGGPATH

hsa00130:Ubiquinone and other terpenoid-quinone biosynthesis

WIKIPATH

WP2762:PTM: gamma carboxylation, hypusine formation and arylsulfatase activation

WHIZPATH

PW000047:Vitamin K Metabolism

WHIZPATH

PW000562:Coagulation

REACPATH

R-HSA-159740:Gamma-carboxylation of protein precursors

目标的 KEGG 通路数据

标题	内容
hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis

目标的 Wiki 路径数据

标题	内容
WP2762	PTM: gamma carboxylation, hypusine formation and arylsulfatase activation

目标的蛋白质ID

标题	内容
TARGETID	T88182
UNIPROID	VKGC_HUMAN
TARGNAME	Vitamin K-dependent gamma-carboxylase (GGCX)
TARGTYPE	Successful target

目标的序列数据

标题	内容
Vitamin K-dependent gamma-carboxylase (GGCX)	MAVSAGSARTSPSSDKVQKDKAELISGPRQDSRIGKLLGFEWTDLSSWRRLVTLLNRPTDPASLAVFRFLFGFLMVLDIPQERGLSSLDRKYLDGLDVCRFPLLDALRPLPLDWMYLVYTIMFLGALGMMLGLCYRISCVLFLLPYWYVFLLDKTSWNNHSYLYGLLAFQLTFMDANHYWSVDGLLNAHRRNAHVPLWNYAVLRGQIFIVYFIAGVKKLDADWVEGYSMEYLSRHWLFSPFKLLLSEELTSLLVVHWGGLLLDLSAGFLLFFDVSRSIGLFFVSYFHCMNSQLFSIGMFSYVMLASSPLFCSPEWPRKLVSYCPRRLQQLLPLKAAPQPSVSCVYKRSRGKSGQKPGLRHQLGAAFTLLYLLEQLFLPYSHFLTQGYNNWTNGLYGYSWDMMVHSRSHQHVKITYRDGRTGELGYLNPGVFTQSRRWKDHADMLKQYATCLSRLLPKYNVTEPQIYFDIWVSINDRFQQRIFDPRVDIVQAAWSPFQRTSWVQPLLMDLSPWRAKLQEIKSSLDNHTEVVFIADFPGLHLENFVSEDLGNTSIQLLQGEVTVELVAEQKNQTLREGEKMQLPAGEYHKVYTTSPSPSCYMYVYVNTTELALEQDLAYLQELKEKVENGSETGPLPPELQPLLEGEVKGGPEPTPLVQTFLRRQQRLQEIERRRNTPFHERFFRFLLRKLYVFRRSFLMTCISLRNLILGRPSLEQLAQEVTYANLRPFEAVGELNPSNTDSSHSNPPESNPDPVHSEF

标题

内容

Vitamin K-dependent gamma-carboxylase (GGCX)

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