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靶点信息23(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Plasma kallikrein messenger RNA (KLKB1 mRNA)
TARGTYPE
Clinical trial target
SYNONYMS
Plasma prekallikrein (mRNA); Plasma kallikrein light chain (mRNA); Plasma kallikrein heavy chain (mRNA); PKK (mRNA); Kininogenin (mRNA); KLK3 (mRNA); Fletcher factor (mRNA)
FUNCTION
It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. The enzyme cleaves Lys-Arg and Arg-Ser bonds.
PDBSTRUC
6O1S; 6O1G; 6I44; 5TJX; 5F8Z
SEQUENCE
MILFKQATYFISLFATVSCGCLTQLYENAFFRGGDVASMYTPNAQYCQMRCTFHPRCLLFSFLPASSINDMEKRFGCFLKDSVTGTLPKVHRTGAVSGHSLKQCGHQISACHRDIYKGVDMRGVNFNVSKVSSVEECQKRCTNNIRCQFFSYATQTFHKAEYRNNCLLKYSPGGTPTAIKVLSNVESGFSLKPCALSEIGCHMNIFQHLAFSDVDVARVLTPDAFVCRTICTYHPNCLFFTFYTNVWKIESQRNVCLLKTSESGTPSSSTPQENTISGYSLLTCKRTLPEPCHSKIYPGVDFGGEELNVTFVKGVNVCQETCTKMIRCQFFTYSLLPEDCKEEKCKCFLRLSMDGSPTRIAYGTQGSSGYSLRLCNTGDNSVCTTKTSTRIVGGTNSSWGEWPWQVSLQVKLTAQRHLCGGSLIGHQWVLTAAHCFDGLPLQDVWRIYSGILNLSDITKDTPFSQIKEIIIHQNYKVSEGNHDIALIKLQAPLNYTEFQKPICLPSKGDTSTIYTNCWVTGWGFSKEKGEIQNILQKVNIPLVTNEECQKRYQDYKITQRMVCAGYKEGGKDACKGDSGGPLVCKHNGMWRLVGITSWGEGCARREQPGVYTKVAEYMDWILEKTQSSDGKAQMQSPA
KEGGPATH
hsa04610:Complement and coagulation cascades
WIKIPATH
WP1818:Formation of Fibrin Clot (Clotting Cascade)
WIKIPATH
WP272:Blood Clotting Cascade
WIKIPATH
WP2806:Human Complement System
WIKIPATH
WP558:Complement and Coagulation Cascades
WHIZPATH
PW000562:Coagulation
REACPATH
R-HSA-140837:Intrinsic Pathway of Fibrin Clot Formation
目标的 Wiki 路径数据
| 标题 | 内容 |
|---|
| WP558 |
|
| WP2806 |
|
| WP272 |
|
| WP1818 |
|
目标的蛋白质ID
| 标题 | 内容 |
|---|
| TARGETID |
|
| UNIPROID |
|
| TARGNAME |
|
| TARGTYPE |
|
目标的序列数据
| 标题 | 内容 |
|---|
| Plasma kallikrein messenger RNA (KLKB1 mRNA) |
|