TARGETID

T87875

FORMERID

TTDC00286

UNIPROID

GLR_HUMAN

TARGNAME

Glucagon receptor messenger RNA (GCGR mRNA)

GENENAME

GCGR

TARGTYPE

Clinical trial target

SYNONYMS

Glucagon receptor (mRNA); GLR (mRNA); GL-R (mRNA)

FUNCTION

Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system. G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis.

PDBSTRUC

5XEZ; 5EE7; 4LF3; 4L6R; 4ERS

BIOCLASS

mRNA target

SEQUENCE

MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF

DRUGINFO

IONIS-GCGR-Rx

DRUGINFO

ISIS-GCGR

DRUGINFO

ISIS 325568

REACPATH

R-HSA-163359:Glucagon signaling in metabolic regulation

REACPATH

R-HSA-416476:G alpha (q) signalling events

REACPATH

R-HSA-418555:G alpha (s) signalling events

REACPATH

R-HSA-420092:Glucagon-type ligand receptors