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靶点信息35(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
N-formyl peptide receptor (FPR1)
TARGTYPE
Clinical trial target
SYNONYMS
N-formylpeptide chemoattractant receptor; FPR1; FPR
FUNCTION
High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors (PubMed:2161213, PubMed:2176894, PubMed:10514456, PubMed:15153520). Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release (PubMed:2161213, PubMed:1712023, PubMed:15153520). This response is mediated via a G-protein that activates a phosphatidylinositol- calcium second messenger system(PubMed:1712023, PubMed:10514456).
SEQUENCE
METNSSLPTNISGGTPAVSAGYLFLDIITYLVFAVTFVLGVLGNGLVIWVAGFRMTHTVTTISYLNLAVADFCFTSTLPFFMVRKAMGGHWPFGWFLCKFVFTIVDINLFGSVFLIALIALDRCVCVLHPVWTQNHRTVSLAKKVIIGPWVMALLLTLPVIIRVTTVPGKTGTVACTFNFSPWTNDPKERINVAVAMLTVRGIIRFIIGFSAPMSIVAVSYGLIATKIHKQGLIKSSRPLRVLSFVAAAFFLCWSPYQVVALIATVRIRELLQGMYKEIGIAVDVTSALAFFNSCLNPMLYVFMGQDFRERLIHALPASLERALTEDSTQTSDTATNSTLPSAEVELQAK
DRUGINFO
group E 1682-2106
目标的 KEGG 通路数据
| 标题 | 内容 |
|---|
| hsa04015 |
|
| hsa04080 |
|
| hsa05150 |
|
目标的 Wiki 路径数据
| 标题 | 内容 |
|---|
| WP455 |
|
| WP2806 |
|
| WP24 |
|
| WP1825 |
|
| WP1824 |
|
目标的蛋白质ID
| 标题 | 内容 |
|---|
| TARGETID |
|
| UNIPROID |
|
| TARGNAME |
|
| TARGTYPE |
|
目标的序列数据
| 标题 | 内容 |
|---|
| N-formyl peptide receptor (FPR1) |
|