TARGETID

T87350

FORMERID

TTDI02317

UNIPROID

PDGFB_HUMAN

TARGNAME

Platelet-derived growth factor B (PDGFB)

GENENAME

PDGFB

TARGTYPE

Clinical trial target

SYNONYMS

SIS; Protooncogene cSis; Proto-oncogene c-Sis; Plateletderived growth factor subunit B; Plateletderived growth factor beta polypeptide; Plateletderived growth factor B chain; Platelet-derived growth factor subunit B; Platelet-derived growth factor beta polypeptide; Platelet-derived growth factor B chain; PDGF2; PDGF-2; PDGF subunit B; Becaplermin

FUNCTION

Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA. Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis.

PDBSTRUC

4QCI; 4HQX; 4HQU; 3MJG; 1PDG

BIOCLASS

Growth factor

SEQUENCE

MNRCWALFLSLCCYLRLVSAEGDPIPEELYEMLSDHSIRSFDDLQRLLHGDPGEEDGAELDLNMTRSHSGGELESLARGRRSLGSLTIAEPAMIAECKTRTEVFEISRRLIDRTNANFLVWPPCVEVQRCSGCCNNRNVQCRPTQVQLRPVQVRKIEIVRKKPIFKKATVTLEDHLACKCETVAAARPVTRSPGGSQEQRAKTPQTRVTIRTVRVRRPPKGKHRKFKHTHDKTALKETLGA

DRUGINFO

PDGF-BB

DRUGINFO

E-10030

DRUGINFO

GAM-501

DRUGINFO

CR-002

KEGGPATH

hsa04010:MAPK signaling pathway

KEGGPATH

hsa04014:Ras signaling pathway

KEGGPATH

hsa04015:Rap1 signaling pathway

KEGGPATH

hsa04060:Cytokine-cytokine receptor interaction

KEGGPATH

hsa04151:PI3K-Akt signaling pathway