TARGETID

T87206

FORMERID

TTDI02165

UNIPROID

S100B_HUMAN

TARGNAME

S100 calcium-binding protein B (S100B)

GENENAME

S100B

TARGTYPE

Clinical trial target

SYNONYMS

S-100 protein subunit beta; S-100 protein beta chain; Protein S100-B

FUNCTION

Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity. Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer.

PDBSTRUC

5D7F; 5CSN; 5CSJ; 5CSI; 5CSF

BIOCLASS

S100 calcium-binding protein

SEQUENCE

MSELEKAMVALIDVFHQYSGREGDKHKLKKSELKELINNELSHFLEEIKEQEVVDKVMETLDNDGDGECDFQEFMAFVAMVTTACHEFFEHE

DRUGINFO

ONO-2506