TARGETID

T87166

FORMERID

TTDC00141

UNIPROID

HXK4_HUMAN

TARGNAME

Glucokinase (GCK)

GENENAME

GCK

TARGTYPE

Clinical trial target

SYNONYMS

Hexokinase type IV; Hexokinase D; HK4; HK IV

FUNCTION

Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting asan insulin-sensitive determinant of hepatic glucose usage.

PDBSTRUC

5V4X; 5V4W; 4RCH; 4NO7; 4MLH

BIOCLASS

Kinase

ECNUMBER

EC 2.7.1.2

SEQUENCE

MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ

DRUGINFO

AMG 151

DRUGINFO

AZD1656

DRUGINFO

GK1-399

DRUGINFO

LY-2599506

DRUGINFO

LY-2608204

DRUGINFO

PF-04937319

DRUGINFO

PF-04991532

DRUGINFO

TTP399