靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T86734

FORMERID

TTDI02002

UNIPROID

GLSK_HUMAN; GLSL_HUMAN

TARGNAME

Glutaminase (GLS)

GENENAME

GLS; GLS2

TARGTYPE

Clinical trial target

SYNONYMS

L-glutamine amidohydrolase; Glutaminase, mitochondrial; GLS

FUNCTION

Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity. Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine.

BIOCLASS

Carbon-nitrogen hydrolase

SEQUENCE

MMRLRGSGMLRDLLLRSPAGVSATLRRAQPLVTLCRRPRGGGRPAAGPAAAARLHPWWGGGGWPAEPLARGLSSSPSEILQELGKGSTHPQPGVSPPAAPAAPGPKDGPGETDAFGNSEGKELVASGENKIKQGLLPSLEDLLFYTIAEGQEKIPVHKFITALKSTGLRTSDPRLKECMDMLRLTLQTTSDGVMLDKDLFKKCVQSNIVLLTQAFRRKFVIPDFMSFTSHIDELYESAKKQSGGKVADYIPQLAKFSPDLWGVSVCTVDGQRHSTGDTKVPFCLQSCVKPLKYAIAVNDLGTEYVHRYVGKEPSGLRFNKLFLNEDDKPHNPMVNAGAIVVTSLIKQGVNNAEKFDYVMQFLNKMAGNEYVGFSNATFQSERESGDRNFAIGYYLKEKKCFPEGTDMVGILDFYFQLCSIEVTCESASVMAATLANGGFCPITGERVLSPEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSGVAGGILLVVPNVMGMMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYDNLRHFAKKLDPRREGGDQRVKSVINLLFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAAEGHVEVVKFLLEACKVNPFPKDRWNNTPMDEALHFGHHDVFKILQEYQVQYTPQGDSDNGKENQTVHKNLDGLL

DRUGINFO

D01PBW

CB-839

Phase 2

DRUGINFO

D0G4YI

PMID30273516-Compound-1

Patented

DRUGINFO

D05TBZ

PMID30273516-Compound-12

Patented

DRUGINFO

D01RUI

PMID30273516-Compound-13

Patented

DRUGINFO

D0YE0P

PMID30273516-Compound-14

Patented

DRUGINFO

D0KN6L

PMID30273516-Compound-15

Patented

DRUGINFO

D02IVA

PMID30273516-Compound-22a

Patented

DRUGINFO

D07KON

PMID30273516-Compound-22b

Patented

DRUGINFO

D05CXZ

PMID30273516-Compound-37

Patented

DRUGINFO

D07IQM

PMID30273516-Compound-38

Patented

目标的 KEGG 通路数据

标题	内容
hsa00220	Arginine biosynthesis
hsa00250	Alanine, aspartate and glutamate metabolism
hsa00471	D-Glutamine and D-glutamate metabolism
hsa01100	Metabolic pathways
hsa04724	Glutamatergic synapse
hsa04727	GABAergic synapse
hsa04964	Proximal tubule bicarbonate reclamation
hsa05206	MicroRNAs in cancer
hsa05230	Central carbon metabolism in cancer

目标的 Wiki 路径数据

标题	内容

目标的蛋白质ID

标题	内容
TARGETID	T86734
UNIPROID	GLSK_HUMAN; GLSL_HUMAN
TARGNAME	Glutaminase (GLS)
TARGTYPE	Clinical Trial target

目标的序列数据

标题	内容
Glutaminase (GLS)	MMRLRGSGMLRDLLLRSPAGVSATLRRAQPLVTLCRRPRGGGRPAAGPAAAARLHPWWGGGGWPAEPLARGLSSSPSEILQELGKGSTHPQPGVSPPAAPAAPGPKDGPGETDAFGNSEGKELVASGENKIKQGLLPSLEDLLFYTIAEGQEKIPVHKFITALKSTGLRTSDPRLKECMDMLRLTLQTTSDGVMLDKDLFKKCVQSNIVLLTQAFRRKFVIPDFMSFTSHIDELYESAKKQSGGKVADYIPQLAKFSPDLWGVSVCTVDGQRHSTGDTKVPFCLQSCVKPLKYAIAVNDLGTEYVHRYVGKEPSGLRFNKLFLNEDDKPHNPMVNAGAIVVTSLIKQGVNNAEKFDYVMQFLNKMAGNEYVGFSNATFQSERESGDRNFAIGYYLKEKKCFPEGTDMVGILDFYFQLCSIEVTCESASVMAATLANGGFCPITGERVLSPEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSGVAGGILLVVPNVMGMMCWSPPLDKMGNSVKGIHFCHDLVSLCNFHNYDNLRHFAKKLDPRREGGDQRVKSVINLLFAAYTGDVSALRRFALSAMDMEQRDYDSRTALHVAAAEGHVEVVKFLLEACKVNPFPKDRWNNTPMDEALHFGHHDVFKILQEYQVQYTPQGDSDNGKENQTVHKNLDGLL

标题

内容

Glutaminase (GLS)

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