TARGETID

T85799

FORMERID

TTDC00165

UNIPROID

CDK4_HUMAN

TARGNAME

Cyclin-dependent kinase 4 (CDK4)

GENENAME

CDK4

TARGTYPE

Successful target

SYNONYMS

PSK-J3; Cell division protein kinase 4

FUNCTION

Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition.

PDBSTRUC

5FWP; 5FWM; 5FWL; 5FWK; 3G33

BIOCLASS

Kinase

ECNUMBER

EC 2.7.11.22

SEQUENCE

MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE

DRUGINFO

Apremilast

DRUGINFO

LY2835219

DRUGINFO

Palbociclib

DRUGINFO

Ribociclib Succinate

DRUGINFO

Trilaciclib

DRUGINFO

LEE011

DRUGINFO

G1T38

DRUGINFO

P-276