TARGETID

T85309

FORMERID

TTDR00526

UNIPROID

CBS_HUMAN

TARGNAME

Cystathionine beta-synthase (CBS)

GENENAME

CBS

TARGTYPE

Clinical trial target

SYNONYMS

Serine sulfhydrase; Beta-thionase

FUNCTION

Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine. Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons.

PDBSTRUC

5MMS; 4UUU; 4PCU; 4L3V; 4L28

BIOCLASS

Alpha-carbonic anhydrase

ECNUMBER

EC 4.2.1.22

SEQUENCE

MPSETPQAEVGPTGCPHRSGPHSAKGSLEKGSPEDKEAKEPLWIRPDAPSRCTWQLGRPASESPHHHTAPAKSPKILPDILKKIGDTPMVRINKIGKKFGLKCELLAKCEFFNAGGSVKDRISLRMIEDAERDGTLKPGDTIIEPTSGNTGIGLALAAAVRGYRCIIVMPEKMSSEKVDVLRALGAEIVRTPTNARFDSPESHVGVAWRLKNEIPNSHILDQYRNASNPLAHYDTTADEILQQCDGKLDMLVASVGTGGTITGIARKLKEKCPGCRIIGVDPEGSILAEPEELNQTEQTTYEVEGIGYDFIPTVLDRTVVDKWFKSNDEEAFTFARMLIAQEGLLCGGSAGSTVAVAVKAAQELQEGQRCVVILPDSVRNYMTKFLSDRWMLQKGFLKEEDLTEKKPWWWHLRVQELGLSAPLTVLPTITCGHTIEILREKGFDQAPVVDEAGVILGMVTLGNMLSSLLAGKVQPSDQVGKVIYKQFKQIRLTDTLGRLSHILEMDHFALVVHEQIQYHSTGKSSQRQMVFGVVTAIDLLNFVAAQERDQK

DRUGINFO

OT-58

DRUGINFO

aminooxyacetic acid

DRUGINFO

Heme

KEGGPATH

hsa00260:Glycine, serine and threonine metabolism

KEGGPATH

hsa00270:Cysteine and methionine metabolism

KEGGPATH

hsa01100:Metabolic pathways

KEGGPATH

hsa01130:Biosynthesis of antibiotics

KEGGPATH

hsa01230:Biosynthesis of amino acids