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靶点信息16(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Human papillomavirus protein E7 (HPV E7)
TARGTYPE
Clinical trial target
FUNCTION
E7 protein has both transforming and trans-activating activities. Disrupts the function of host retinoblastoma protein RB1/pRb, which is a key regulator of the cell cycle. Induces the disassembly of the E2F1 transcription factors from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. Interferes with histone deacetylation mediated by HDAC1 and HDAC2, leading to activation of transcription.
BIOCLASS
Papillomaviridae E protein
SEQUENCE
MHGDTPTLHEYMLDLQPETTDLYCYEQLNDSSEEEDEIDGPAGQAEPDRAHYNIVTFCCKCDSTLRLCVQSTHVDIRTLEDLLMGTLGIVCPICSQKP
DRUGINFO
Tipapkinogene sovacivec
目标的蛋白质ID
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目标的序列数据
| 标题 | 内容 |
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| Human papillomavirus protein E7 (HPV E7) |
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