靶点信息175(本栏目收费,不能显示细节,电话13136136841)
靶点信息
标题
内容
相关药物
状态
TARGETID
T84621
FORMERID
TTDS00420
UNIPROID
C11B1_HUMAN
TARGNAME
Steroid 11-beta-hydroxylase (CYP11B1)
GENENAME
CYP11B1
TARGTYPE
Successful target
SYNONYMS
S11BH; P450C11; P-450c11; CYPXIB1; CYP11B1
FUNCTION
Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB.
PDBSTRUC
6M7X
BIOCLASS
Paired donor oxygen oxidoreductase
ECNUMBER
EC 1.14.15.4
SEQUENCE
MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQGYEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPLLTFRAIN
DRUGINFO
FADROZOLE
DRUGINFO
Metyrapone
DRUGINFO
Osilodrostat
DRUGINFO
(3-((1H-imidazol-1-yl)methyl)phenyl)methanol
DRUGINFO
(4-((1H-imidazol-1-yl)methyl)phenyl)methanol
DRUGINFO
1-(2-Phenoxy-ethyl)-1H-imidazole
DRUGINFO
1-(3,4-dihydronaphthalen-2-yl)-1H-imidazole
DRUGINFO
1-(3-Bromobenzyl)-1H-imidazole
目标的 KEGG 通路数据
标题内容
hsa00140
hsa01100
目标的 Wiki 路径数据
标题内容
WP702
WP43
WP2749
WP2355
目标的蛋白质ID
标题内容
TARGETID
UNIPROID
TARGNAME
TARGTYPE
目标的序列数据
标题内容
Steroid 11-beta-hydroxylase (CYP11B1)
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