靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

WIKIPATH

WP4:Sandbox Pathway

WIKIPATH

WP45:G1 to S cell cycle control

WIKIPATH

WP615:Senescence and Autophagy in Cancer

WIKIPATH

WP673:ErbB Signaling Pathway

WIKIPATH

WP707:DNA Damage Response

WIKIPATH

WP710:DNA Damage Response (only ATM dependent)

REACPATH

R-HSA-111448:Activation of NOXA and translocation to mitochondria

REACPATH

R-HSA-139915:Activation of PUMA and translocation to mitochondria

REACPATH

R-HSA-1912408:Pre-NOTCH Transcription and Translation

REACPATH

R-HSA-2559580:Oxidative Stress Induced Senescence

REACPATH

R-HSA-2559584:Formation of Senescence-Associated Heterochromatin Foci (SAHF)

REACPATH

R-HSA-2559585:Oncogene Induced Senescence

REACPATH

R-HSA-2559586:DNA Damage/Telomere Stress Induced Senescence

REACPATH

R-HSA-349425:Autodegradation of the E3 ubiquitin ligase COP1

REACPATH

R-HSA-5628897:TP53 Regulates Metabolic Genes

REACPATH

R-HSA-5693565:Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks

REACPATH

R-HSA-69541:Stabilization of p53

REACPATH

R-HSA-983231:Factors involved in megakaryocyte development and platelet production

NET_PATH

NetPath_25:FSH Signaling Pathway

INTEPATH

ap1_pathway:AP-1 transcription factor network

目标的 KEGG 通路数据

标题	内容
hsa05016	Huntington's disease
hsa05160	Hepatitis C
hsa05161	Hepatitis B
hsa05162	Measles
hsa05166	HTLV-I infection
hsa05168	Herpes simplex infection
hsa05169	Epstein-Barr virus infection
hsa05200	Pathways in cancer
hsa05202	Transcriptional misregulation in cancer
hsa05203	Viral carcinogenesis
hsa05205	Proteoglycans in cancer
hsa05206	MicroRNAs in cancer
hsa05210	Colorectal cancer
hsa05212	Pancreatic cancer
hsa05213	Endometrial cancer
hsa05214	Glioma
hsa05215	Prostate cancer
hsa05216	Thyroid cancer
hsa05217	Basal cell carcinoma
hsa05218	Melanoma
hsa05219	Bladder cancer
hsa05220	Chronic myeloid leukemia
hsa05222	Small cell lung cancer
hsa05223	Non-small cell lung cancer
hsa05230	Central carbon metabolism in cancer
hsa04010	MAPK signaling pathway
hsa04071	Sphingolipid signaling pathway
hsa04110	Cell cycle
hsa04115	p53 signaling pathway
hsa04151	PI3K-Akt signaling pathway
hsa04210	Apoptosis
hsa04310	Wnt signaling pathway
hsa04722	Neurotrophin signaling pathway
hsa04919	Thyroid hormone signaling pathway
hsa05014	Amyotrophic lateral sclerosis (ALS)

目标的 Wiki 路径数据

标题	内容
WP710	DNA Damage Response (only ATM dependent)
WP707	DNA Damage Response
WP673	ErbB Signaling Pathway
WP615	Senescence and Autophagy in Cancer
WP45	G1 to S cell cycle control
WP4	Sandbox Pathway
WP399	Wnt Signaling Pathway and Pluripotency
WP366	TGF beta Signaling Pathway
WP3286	Copper homeostasis
WP2828	Bladder Cancer
WP2815	Mammary gland development pathway - Involution (Stage 4 of 4)
WP2786	Pre-NOTCH Expression and Processing
WP254	Apoptosis
WP2516	ATM Signaling Pathway
WP2447	Amyotrophic lateral sclerosis (ALS)
WP2446	Retinoblastoma (RB) in Cancer
WP2431	Spinal Cord Injury
WP2377	Integrated Pancreatic Cancer Pathway
WP2374	Oncostatin M Signaling Pathway
WP2363	Gastric cancer network 2
WP2263	Prostate Cancer
WP2261	Signaling Pathways in Glioblastoma
WP2249	Metastatic brain tumor
WP2059	Alzheimers Disease
WP1984	Integrated Breast Cancer Pathway
WP1971	Integrated Cancer pathway
WP1841	Intrinsic Pathway for Apoptosis
WP1815	Factors involved in megakaryocyte development and platelet production
WP179	Cell Cycle
WP1775	Cell Cycle Checkpoints
WP1772	Apoptosis Modulation and Signaling
WP176	Folate Metabolism
WP1742	TP53 Network
WP1601	Fluoropyrimidine Activity
WP1545	miRNAs involved in DNA damage response
WP1530	miRNA Regulation of DNA Damage Response
WP1403	AMPK Signaling

目标的蛋白质ID

标题	内容
TARGETID	T82051
UNIPROID	P53_HUMAN
TARGNAME	P53 messenger RNA (TP53 mRNA)
TARGTYPE	Clinical Trial target

目标的序列数据

标题	内容
P53 messenger RNA (TP53 mRNA)	MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD

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