靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

DRUGINFO

HHCYH33

DRUGINFO

PWT-33597

DRUGINFO

ETP-46321

KEGGPATH

hsa00562:Inositol phosphate metabolism

KEGGPATH

hsa04012:ErbB signaling pathway

KEGGPATH

hsa04014:Ras signaling pathway

KEGGPATH

hsa04015:Rap1 signaling pathway

KEGGPATH

hsa04022:cGMP-PKG signaling pathway

KEGGPATH

hsa04024:cAMP signaling pathway

KEGGPATH

hsa04062:Chemokine signaling pathway

KEGGPATH

hsa04066:HIF-1 signaling pathway

KEGGPATH

hsa04068:FoxO signaling pathway

KEGGPATH

hsa04070:Phosphatidylinositol signaling system

KEGGPATH

hsa04071:Sphingolipid signaling pathway

KEGGPATH

hsa04150:mTOR signaling pathway

KEGGPATH

hsa04151:PI3K-Akt signaling pathway

KEGGPATH

hsa04152:AMPK signaling pathway

KEGGPATH

hsa04210:Apoptosis

KEGGPATH

hsa04261:Adrenergic signaling in cardiomyocytes

KEGGPATH

hsa04370:VEGF signaling pathway

目标的 KEGG 通路数据

标题	内容
hsa00562	Inositol phosphate metabolism
hsa04012	ErbB signaling pathway
hsa04014	Ras signaling pathway
hsa04015	Rap1 signaling pathway
hsa04022	cGMP-PKG signaling pathway
hsa04024	cAMP signaling pathway
hsa04062	Chemokine signaling pathway
hsa04066	HIF-1 signaling pathway
hsa04068	FoxO signaling pathway
hsa04070	Phosphatidylinositol signaling system
hsa04071	Sphingolipid signaling pathway
hsa04150	mTOR signaling pathway
hsa04151	PI3K-Akt signaling pathway
hsa04152	AMPK signaling pathway
hsa04210	Apoptosis
hsa04261	Adrenergic signaling in cardiomyocytes
hsa04370	VEGF signaling pathway
hsa04380	Osteoclast differentiation
hsa04510	Focal adhesion
hsa04550	Signaling pathways regulating pluripotency of stem cells
hsa04611	Platelet activation
hsa04620	Toll-like receptor signaling pathway
hsa04630	Jak-STAT signaling pathway
hsa04650	Natural killer cell mediated cytotoxicity
hsa04660	T cell receptor signaling pathway
hsa04662	B cell receptor signaling pathway
hsa04664	Fc epsilon RI signaling pathway
hsa04666	Fc gamma R-mediated phagocytosis
hsa04668	TNF signaling pathway
hsa04670	Leukocyte transendothelial migration
hsa04722	Neurotrophin signaling pathway
hsa04725	Cholinergic synapse
hsa04750	Inflammatory mediator regulation of TRP channels
hsa04810	Regulation of actin cytoskeleton
hsa04910	Insulin signaling pathway
hsa04914	Progesterone-mediated oocyte maturation
hsa04915	Estrogen signaling pathway
hsa04917	Prolactin signaling pathway
hsa04919	Thyroid hormone signaling pathway
hsa04921	Oxytocin signaling pathway
hsa04923	Regulation of lipolysis in adipocytes
hsa04930	Type II diabetes mellitus
hsa04932	Non-alcoholic fatty liver disease (NAFLD)
hsa04960	Aldosterone-regulated sodium reabsorption
hsa04973	Carbohydrate digestion and absorption
hsa05100	Bacterial invasion of epithelial cells
hsa05142	Chagas disease (American trypanosomiasis)
hsa05145	Toxoplasmosis
hsa05146	Amoebiasis
hsa05160	Hepatitis C
hsa05161	Hepatitis B
hsa05162	Measles
hsa05164	Influenza A
hsa05166	HTLV-I infection
hsa05169	Epstein-Barr virus infection
hsa05200	Pathways in cancer
hsa05203	Viral carcinogenesis
hsa05205	Proteoglycans in cancer
hsa05206	MicroRNAs in cancer
hsa05210	Colorectal cancer
hsa05211	Renal cell carcinoma
hsa05212	Pancreatic cancer
hsa05213	Endometrial cancer
hsa05214	Glioma
hsa05215	Prostate cancer
hsa05218	Melanoma
hsa05220	Chronic myeloid leukemia
hsa05221	Acute myeloid leukemia
hsa05222	Small cell lung cancer
hsa05223	Non-small cell lung cancer
hsa05230	Central carbon metabolism in cancer
hsa05231	Choline metabolism in cancer

目标的 Wiki 路径数据

标题	内容
WP75	Toll-like receptor signaling pathway
WP722	Serotonin HTR1 Group and FOS Pathway
WP710	DNA Damage Response (only ATM dependent)
WP524	G13 Signaling Pathway
WP51	Regulation of Actin Cytoskeleton
WP481	Insulin Signaling
WP395	IL-4 Signaling Pathway
WP313	Signaling of Hepatocyte Growth Factor Receptor
WP3	Transcriptional activation by NRF2
WP2865	IL1 and megakaryotyces in obesity
WP2781	Signaling by ERBB4
WP2780	Signaling by ERBB2
WP2759	Fc epsilon receptor (FCERI) signaling
WP2747	PI Metabolism
WP2732	Interleukin-2 signaling
WP2719	Fcgamma receptor (FCGR) dependent phagocytosis
WP2713	Signaling by SCF-KIT
WP2694	DAP12 interactions
WP2677	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
WP2664	Gastrin-CREB signalling pathway via PKC and MAPK
WP2653	PIP3 activates AKT signaling
WP2377	Integrated Pancreatic Cancer Pathway
WP2263	Prostate Cancer
WP2261	Signaling Pathways in Glioblastoma
WP2203	TSLP Signaling Pathway
WP2038	Regulation of Microtubule Cytoskeleton
WP2032	TSH signaling pathway
WP1982	SREBP signalling
WP1927	TCR signaling
WP1916	Signaling by PDGF
WP1913	Signaling by Insulin receptor
WP1911	Signaling by FGFR
WP1910	Signaling by EGFR
WP1873	NGF signalling via TRKA from the plasma membrane
WP1867	Nephrin interactions
WP1840	Interleukin-3, 5 and GM-CSF signaling
WP1826	GPVI-mediated activation cascade
WP1824	GPCR downstream signaling
WP1799	Costimulation by the CD28 family
WP1794	Cell surface interactions at the vascular wall
WP1544	MicroRNAs in cardiomyocyte hypertrophy
WP1539	Angiogenesis
WP1449	Regulation of toll-like receptor signaling pathway
WP1403	AMPK Signaling

目标的蛋白质ID

标题	内容
TARGETID	T80276
UNIPROID	PK3CA_HUMAN
TARGNAME	PI3-kinase alpha (PIK3CA)
TARGTYPE	Successful target

目标的序列数据

标题	内容
PI3-kinase alpha (PIK3CA)	MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQLLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFAIGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKHIYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLKLCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMDCFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGIYHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHCPLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWFSSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLKAISTRDPLSEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAMELLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTNQRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILKQEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLWLNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIAYIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN

标题

内容

PI3-kinase alpha (PIK3CA)

MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQLLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFAIGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKHIYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLKLCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMDCFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGIYHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHCPLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWFSSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLKAISTRDPLSEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAMELLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTNQRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILKQEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLWLNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRSCAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIAYIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN

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