TARGETID

T79232

FORMERID

TTDS00109

UNIPROID

V1AR_HUMAN

TARGNAME

Vasopressin V1a receptor (V1AR)

GENENAME

AVPR1A

TARGTYPE

Successful target

SYNONYMS

Vascular/hepatic-type arginine vasopressin receptor; V1aR; V1a vasopressin receptor; Antidiuretic hormone receptor 1a; AVPR1; AVPR V1a

FUNCTION

The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation and attachment. Receptor for arginine vasopressin.

PDBSTRUC

1YTV

BIOCLASS

GPCR rhodopsin

SEQUENCE

MRLSAGPDAGPSGNSSPWWPLATGAGNTSREAEALGEGNGPPRDVRNEELAKLEIAVLAVTFAVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQMCWDITYRFRGPDWLCRVVKHLQVFGMFASAYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIAAAWVLSFVLSTPQYFVFSMIEVNNVTKARDCWATFIQPWGSRAYVTWMTGGIFVAPVVILGTCYGFICYNIWCNVRGKTASRQSKGAEQAGVAFQKGFLLAPCVSSVKSISRAKIRTVKMTFVIVTAYIVCWAPFFIIQMWSVWDPMSVWTESENPTITITALLGSLNSCCNPWIYMFFSGHLLQDCVQSFPCCQNMKEKFNKEDTDSMSRRQTFYSNNRSPTNSTGMWKDSPKSSKSIKFIPVST

DRUGINFO

Conivaptan

DRUGINFO

Desmopressin

DRUGINFO

Felypressin

DRUGINFO

Mozavaptan

DRUGINFO

Oxytocin

DRUGINFO

Terlipressin

DRUGINFO

ATOSIBAN

DRUGINFO

Balovaptan

DRUGINFO

FE-202158