TARGETID

T79062

FORMERID

TTDR00157

UNIPROID

5HT7R_HUMAN

TARGNAME

5-HT 7 receptor (HTR7)

GENENAME

HTR7

TARGTYPE

Clinical trial target

SYNONYMS

Serotonin receptor 7; 5HT7; 5-hydroxytryptamine receptor 7; 5-HT7 receptor; 5-HT7; 5-HT-X; 5-HT-7

FUNCTION

The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen.

BIOCLASS

GPCR rhodopsin

SEQUENCE

MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD

DRUGINFO

AVN-101

DRUGINFO

JNJ-18038683

DRUGINFO

RP5063

DRUGINFO

ATI-9242

DRUGINFO

4-oxadiazole derivative 1

DRUGINFO

Carbamide derivative 2

DRUGINFO

PMID30124346-Compound-13TABLE4

DRUGINFO

PMID30124346-Compound-34TABLE4

DRUGINFO

SB-269970

DRUGINFO

(+/-)-nantenine