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靶点信息23(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Tissue factor pathway inhibitor (TFPI)
TARGTYPE
Clinical trial target
SYNONYMS
TFPI1; Lipoprotein-associated coagulation inhibitor; LACI; Extrinsic pathway inhibitor; EPI
FUNCTION
It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma. Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex.
PDBSTRUC
6BX8; 5NMV; 4DTG; 4BQD; 1TFX
SEQUENCE
MIYTMKKVHALWASVCLLLNLAPAPLNADSEEDEEHTIITDTELPPLKLMHSFCAFKADDGPCKAIMKRFFFNIFTRQCEEFIYGGCEGNQNRFESLEECKKMCTRDNANRIIKTTLQQEKPDFCFLEEDPGICRGYITRYFYNNQTKQCERFKYGGCLGNMNNFETLEECKNICEDGPNGFQVDNYGTQLNAVNNSLTPQSTKVPSLFEFHGPSWCLTPADRGLCRANENRFYYNSVIGKCRPFKYSGCGGNENNFTSKQECLRACKKGFIQRISKGGLIKTKRKRKKQRVKIAYEEIFVKNM
KEGGPATH
hsa04610:Complement and coagulation cascades
WIKIPATH
WP1818:Formation of Fibrin Clot (Clotting Cascade)
WIKIPATH
WP1984:Integrated Breast Cancer Pathway
WIKIPATH
WP558:Complement and Coagulation Cascades
REACPATH
R-HSA-140834:Extrinsic Pathway of Fibrin Clot Formation
NET_PATH
NetPath_16:IL4 Signaling Pathway
目标的蛋白质ID
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目标的序列数据
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| Tissue factor pathway inhibitor (TFPI) |
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