TARGETID

T78277

FORMERID

TTDI01982

UNIPROID

ASGL1_HUMAN

TARGNAME

Asparaginase (ASRGL1)

GENENAME

ASRGL1

TARGTYPE

Successful target

SYNONYMS

Lasparagine amidohydrolase; Isoaspartyl peptidase/Lasparaginase beta chain; Isoaspartyl peptidase/Lasparaginase; Isoaspartyl dipeptidase; Betaaspartylpeptidase; Asparaginaselike protein 1; ASRGL1

FUNCTION

Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L- Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine.

PDBSTRUC

4ZM9; 4PVS; 4PVR; 4PVQ; 4PVP

BIOCLASS

Peptidase

ECNUMBER

EC 3.4.19.5

SEQUENCE

MNPIVVVHGGGAGPISKDRKERVHQGMVRAATVGYGILREGGSAVDAVEGAVVALEDDPEFNAGCGSVLNTNGEVEMDASIMDGKDLSAGAVSAVQCIANPIKLARLVMEKTPHCFLTDQGAAQFAAAMGVPEIPGEKLVTERNKKRLEKEKHEKGAQKTDCQKNLGTVGAVALDCKGNVAYATSTGGIVNKMVGRVGDSPCLGAGGYADNDIGAVSTTGHGESILKVNLARLTLFHIEQGKTVEEAADLSLGYMKSRVKGLGGLIVVSKTGDWVAKWTSTSMPWAAAKDGKLHFGIDPDDTTITDLP

DRUGINFO

Calaspargase pegol

DRUGINFO

GRASPA

WHIZPATH

PW000002:Aspartate Metabolism

WHIZPATH

PW000009:Ammonia Recycling

BIOCPATH

ASPARAGINE-DEG1-PWY-1:Asparagine degradation