TARGETID

T77913

FORMERID

TTDS00086

UNIPROID

HRH1_HUMAN

TARGNAME

Histamine H1 receptor (H1R)

GENENAME

HRH1

TARGTYPE

Successful target

SYNONYMS

HH1R; H1R

FUNCTION

In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.

PDBSTRUC

3RZE

BIOCLASS

GPCR rhodopsin

SEQUENCE

MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSRTDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRILHIRS

DRUGINFO

(S)-(+)-Dimethindene maleate

DRUGINFO

Aceprometazine

DRUGINFO

Acrivastine

DRUGINFO

Alcaftadine

DRUGINFO

Antazoline

DRUGINFO

Azatadine

DRUGINFO

Azelastine

DRUGINFO

Bepotastine

DRUGINFO

Bromodiphenhydramine