靶点信息30(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Bacterial Beta-ketoacyl-ACP synthase III (Bact fabH)
TARGTYPE
Literature-reported target
SYNONYMS
KAS III; FabH; EcFabH; Condensing enzyme FabH; Beta-ketoacyl-acyl carrier protein synthase III; Acetoacetyl-acyl carrier protein synthase; Acetoacetyl-ACP synthase; 3-oxoacyl-[acyl-carrier-protein] synthase III
FUNCTION
Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Has some substrate specificity for acetyl-CoA. Its substrate specificity determines the biosynthesis of straight-chain of fatty acids instead of branched-chain.
PDBSTRUC
5BNS; 5BNR; 5BNM; 4Z8D; 3IL9
SEQUENCE
MYTKIIGTGSYLPEQVRTNADLEKMVDTSDEWIVTRTGIRERHIAAPNETVSTMGFEAATRAIEMAGIEKDQIGLIVVATTSATHAFPSAACQIQSMLGIKGCPAFDVAAACAGFTYALSVADQYVKSGAVKYALVVGSDVLARTCDPTDRGTIIIFGDGAGAAVLAASEEPGIISTHLHADGSYGELLTLPNADRVNPENSIHLTMAGNEVFKVAVTELAHIVDETLAANNLDRSQLDWLVPHQANLRIISATAKKLGMSMDNVVVTLDRHGNTSAASVPCALDEAVRDGRIKPGQLVLLEAFGGGFTWGSALVRF
DRUGINFO
2-(3-Phenoxy-benzoylamino)-benzoic acid
DRUGINFO
2-(4-Bromo-3-phenoxy-benzoylamino)-benzoic acid
DRUGINFO
2-(4-chlorophenylsulfonyl)naphthalene-1,4-diol
DRUGINFO
2-(4-Fluoro-3-phenoxy-benzoylamino)-benzoic acid
DRUGINFO
2-(4-propylphenylsulfonyl)naphthalene-1,4-diol
DRUGINFO
2-(methylsulfonyl)naphthalene-1,4-diol
DRUGINFO
2-(naphthalen-2-ylsulfonyl)naphthalene-1,4-diol
DRUGINFO
2-(phenylsulfonyl)naphthalene-1,4-diol
目标的蛋白质ID
| 标题 | 内容 |
|---|
| TARGETID |
|
| UNIPROID |
|
| TARGNAME |
|
| TARGTYPE |
|
目标的序列数据
| 标题 | 内容 |
|---|
| Bacterial Beta-ketoacyl-ACP synthase III (Bact fabH) |
|