TARGETID

T72038

FORMERID

TTDR00804

UNIPROID

LEG3_HUMAN

TARGNAME

Galectin-3 (LGALS3)

GENENAME

LGALS3

TARGTYPE

Clinical trial target

SYNONYMS

Mac-2 antigen; MAC2; Lectin L-29; Laminin-binding protein; L-31; IgE-binding protein; Galactoside-binding protein; Galactose-specific lectin 3; Gal-3; GALBP; Carbohydrate-binding protein 35; Carbohydrate binding protein 35; CBP 35; Beta-galactoside-binding protein LGALS3; 35 kDa lectin

FUNCTION

May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage with mobilization of the core autophagy regulators ATG16L1 and BECN1 in response to damaged endomembranes. Galactose-specific lectin which binds IgE.

PDBSTRUC

6QGF; 6QGE; 6I78; 6I77; 6I76

SEQUENCE

MADNFSLHDALSGSGNPNPQGWPGAWGNQPAGAGGYPGASYPGAYPGQAPPGAYPGQAPPGAYPGAPGAYPGAPAPGVYPGPPSGPGAYPSSGQPSATGAYPATGPYGAPAGPLIVPYNLPLPGGVVPRMLITILGTVKPNANRIALDFQRGNDVAFHFNPRFNENNRRVIVCNTKLDNNWGREERQSVFPFESGKPFKIQVLVEPDHFKVAVNDAHLLQYNHRVKKLNEISKLGISGDIDLTSASYTMI

DRUGINFO

GR-MD-02

DRUGINFO

2,3,5,6-Tetrafluoro-4-Methoxy-Benzamide

DRUGINFO

PFFFFF

WIKIPATH

WP1781:Advanced glycosylation endproduct receptor signaling

WIKIPATH

WP2324:AGE/RAGE pathway

WIKIPATH

WP2431:Spinal Cord Injury

REACPATH

R-HSA-879415:Advanced glycosylation endproduct receptor signaling

NET_PATH

NetPath_7:TGF_beta_Receptor Signaling Pathway

INTEPATH

hedgehog_glipathway:Hedgehog signaling events mediated by Gli proteins

INTEPATH

ras_pathway:Regulation of Ras family activation