靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

WIKIPATH

WP710:DNA Damage Response (only ATM dependent)

REACPATH

R-HSA-195253:Degradation of beta-catenin by the destruction complex

REACPATH

R-HSA-198323:AKT phosphorylates targets in the cytosol

REACPATH

R-HSA-3371453:Regulation of HSF1-mediated heat shock response

REACPATH

R-HSA-399956:CRMPs in Sema3A signaling

REACPATH

R-HSA-4641262:Disassembly of the destruction complex and recruitment of AXIN to the membrane

REACPATH

R-HSA-5358747:S33 mutants of beta-catenin aren't phosphorylated

REACPATH

R-HSA-5358749:S37 mutants of beta-catenin aren't phosphorylated

REACPATH

R-HSA-5358751:S45 mutants of beta-catenin aren't phosphorylated

REACPATH

R-HSA-5358752:T41 mutants of beta-catenin aren't phosphorylated

REACPATH

R-HSA-5610783:Degradation of GLI2 by the proteasome

REACPATH

R-HSA-5674400:Constitutive Signaling by AKT1 E17K in Cancer

INTEPATH

ar_tf_pathway:Regulation of Androgen receptor activity

INTEPATH

aurora_a_pathway:Aurora A signaling

INTEPATH

betacatenin_deg_pathway:Degradation of beta catenin

INTEPATH

bmppathway:BMP receptor signaling

INTEPATH

cdc42_pathway:CDC42 signaling events

INTEPATH

deltanp63pathway:Validated transcriptional targets of deltaNp63 isoforms

INTEPATH

hedgehog_glipathway:Hedgehog signaling events mediated by Gli proteins

INTEPATH

ilk_pathway:Integrin-linked kinase signaling

目标的 KEGG 通路数据

标题	内容
hsa04340	Hedgehog signaling pathway
hsa04360	Axon guidance
hsa04390	Hippo signaling pathway
hsa04510	Focal adhesion
hsa04550	Signaling pathways regulating pluripotency of stem cells
hsa04660	T cell receptor signaling pathway
hsa04662	B cell receptor signaling pathway
hsa04722	Neurotrophin signaling pathway
hsa04728	Dopaminergic synapse
hsa04910	Insulin signaling pathway
hsa04916	Melanogenesis
hsa04917	Prolactin signaling pathway
hsa04919	Thyroid hormone signaling pathway
hsa04932	Non-alcoholic fatty liver disease (NAFLD)
hsa05010	Alzheimer's disease
hsa05160	Hepatitis C
hsa05162	Measles
hsa05164	Influenza A
hsa05166	HTLV-I infection
hsa05169	Epstein-Barr virus infection
hsa05200	Pathways in cancer
hsa05210	Colorectal cancer
hsa05213	Endometrial cancer
hsa05215	Prostate cancer
hsa05217	Basal cell carcinoma
hsa04012	ErbB signaling pathway
hsa04062	Chemokine signaling pathway
hsa04110	Cell cycle
hsa04151	PI3K-Akt signaling pathway
hsa04310	Wnt signaling pathway

目标的 Wiki 路径数据

标题	内容
WP710	DNA Damage Response (only ATM dependent)
WP615	Senescence and Autophagy in Cancer
WP61	Notch Signaling Pathway
WP500	Glycogen Metabolism
WP481	Insulin Signaling
WP428	Wnt Signaling Pathway
WP399	Wnt Signaling Pathway and Pluripotency
WP364	IL-6 signaling pathway
WP363	Wnt Signaling Pathway Netpath
WP3286	Copper homeostasis
WP306	Focal Adhesion
WP2804	Hair Follicle Development: Induction (Part 1 of 3)
WP2795	Cardiac Hypertrophic Response
WP2773	Degradation of beta-catenin by the destruction complex
WP2583	T-Cell Receptor and Co-stimulatory Signaling
WP2406	Cardiac Progenitor Differentiation
WP2380	BDNF signaling pathway
WP2355	Corticotropin-releasing hormone
WP23	B Cell Receptor Signaling Pathway
WP2112	IL17 signaling pathway
WP2064	Neural Crest Differentiation
WP2059	Alzheimers Disease
WP205	IL-7 Signaling Pathway
WP2038	Regulation of Microtubule Cytoskeleton
WP2036	TWEAK Signaling Pathway
WP2034	Leptin signaling pathway
WP1907	Semaphorin interactions
WP179	Cell Cycle
WP1544	MicroRNAs in cardiomyocyte hypertrophy
WP138	Androgen receptor signaling pathway
WP127	IL-5 Signaling Pathway

目标的蛋白质ID

标题	内容
TARGETID	T70977
UNIPROID	GSK3B_HUMAN
TARGNAME	Glycogen synthase kinase-3 beta (GSK-3B)
TARGTYPE	Clinical Trial target

目标的序列数据

标题	内容
Glycogen synthase kinase-3 beta (GSK-3B)	MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST

标题

内容

Glycogen synthase kinase-3 beta (GSK-3B)

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