TARGETID

T69991

FORMERID

TTDC00256

UNIPROID

WEE1_HUMAN

TARGNAME

Wee1-like protein kinase (WEE1)

GENENAME

WEE1

TARGTYPE

Clinical trial target

SYNONYMS

Wee1A kinase; WEE1hu

FUNCTION

Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation. Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'.

PDBSTRUC

5VDA; 5VD9; 5VD8; 5VD7; 5VD5

BIOCLASS

Kinase

ECNUMBER

EC 2.7.10.2

SEQUENCE

MSFLSRQQPPPPRRAGAACTLRQKLIFSPCSDCEEEEEEEEEEGSGHSTGEDSAFQEPDSPLPPARSPTEPGPERRRSPGPAPGSPGELEEDLLLPGACPGADEAGGGAEGDSWEEEGFGSSSPVKSPAAPYFLGSSFSPVRCGGPGDASPRGCGARRAGEGRRSPRPDHPGTPPHKTFRKLRLFDTPHTPKSLLSKARGIDSSSVKLRGSSLFMDTEKSGKREFDVRQTPQVNINPFTPDSLLLHSSGQCRRRKRTYWNDSCGEDMEASDYELEDETRPAKRITITESNMKSRYTTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSMSLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQVEEGDSRFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWHEIRQGRLPRIPQVLSQEFTELLKVMIHPDPERRPSAMALVKHSVLLSASRKSAEQLRIELNAEKFKNSLLQKELKKAQMAKAAAEERALFTDRMATRSTTQSNRTSRLIGKKMNRSVSLTIY

DRUGINFO

MK-1775

DRUGINFO

ZN-c3

DRUGINFO

9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione

KEGGPATH

hsa04110:Cell cycle

WIKIPATH

WP1775:Cell Cycle Checkpoints

WIKIPATH

WP179:Cell Cycle

WIKIPATH

WP1815:Factors involved in megakaryocyte development and platelet production

WIKIPATH

WP1858:Mitotic G1-G1/S phases