靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T69563

FORMERID

TTDI02094

UNIPROID

IDHC_HUMAN

TARGNAME

Oxalosuccinate decarboxylase (IDH1)

GENENAME

IDH1

TARGTYPE

Successful target

SYNONYMS

PICD; NADP(+)-specific ICDH; Isocitrate dehydrogenase [NADP] cytoplasmic; IDP; IDH; Cytosolic NADP-isocitrate dehydrogenase

FUNCTION

Catalyses the NADPH-dependent reduction of alpha-ketoglutarate to R(-)-2-hydroxyglutarate (2HG).

PDBSTRUC

6BL2; 6BL1; 6BL0; 6BKZ; 6BKY

BIOCLASS

Short-chain dehydrogenases reductase

ECNUMBER

EC 1.1.1.42

SEQUENCE

MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL

DRUGINFO

Ivosidenib

DRUGINFO

IDH305

DRUGINFO

LY3410738

KEGGPATH

hsa00020:Citrate cycle (TCA cycle)

KEGGPATH

hsa00480:Glutathione metabolism

KEGGPATH

hsa01100:Metabolic pathways

KEGGPATH

hsa01130:Biosynthesis of antibiotics

KEGGPATH

hsa01200:Carbon metabolism

目标的 KEGG 通路数据

标题	内容
hsa00020	Citrate cycle (TCA cycle)
hsa00480	Glutathione metabolism
hsa01100	Metabolic pathways
hsa01130	Biosynthesis of antibiotics
hsa01200	Carbon metabolism
hsa01210	2-Oxocarboxylic acid metabolism
hsa01230	Biosynthesis of amino acids
hsa04146	Peroxisome
hsa05230	Central carbon metabolism in cancer

目标的 Wiki 路径数据

标题	内容
WP2453	TCA Cycle and PDHc
WP2006	miR-targeted genes in squamous cell - TarBase
WP2004	miR-targeted genes in lymphocytes - TarBase
WP2003	miR-targeted genes in leukocytes - TarBase
WP2002	miR-targeted genes in epithelium - TarBase
WP1878	Peroxisomal lipid metabolism
WP100	Glutathione metabolism

目标的蛋白质ID

标题	内容
TARGETID	T69563
UNIPROID	IDHC_HUMAN
TARGNAME	Oxalosuccinate decarboxylase (IDH1)
TARGTYPE	Successful target

目标的序列数据

标题	内容
Oxalosuccinate decarboxylase (IDH1)	MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL

标题

内容

Oxalosuccinate decarboxylase (IDH1)

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