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靶点信息33(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Bone morphogenetic protein 2 (BMP2)
TARGTYPE
Clinical trial target
SYNONYMS
Bone morphogenetic protein 2A; BMP2A; BMP-2A; BMP-2
FUNCTION
Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4. Induces cartilage and bone formation.
PDBSTRUC
6OMN; 4UI2; 4UI1; 4UI0; 4UHZ
SEQUENCE
MVAGTRCLLALLLPQVLLGGAAGLVPELGRRKFAAASSGRPSSQPSDEVLSEFELRLLSMFGLKQRPTPSRDAVVPPYMLDLYRRHSGQPGSPAPDHRLERAASRANTVRSFHHEESLEELPETSGKTTRRFFFNLSSIPTEEFITSAELQVFREQMQDALGNNSSFHHRINIYEIIKPATANSKFPVTRLLDTRLVNQNASRWESFDVTPAVMRWTAQGHANHGFVVEVAHLEEKQGVSKRHVRISRSLHQDEHSWSQIRPLLVTFGHDGKGHPLHKREKRQAKHKQRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR
KEGGPATH
hsa04060:Cytokine-cytokine receptor interaction
KEGGPATH
hsa04340:Hedgehog signaling pathway
KEGGPATH
hsa04350:TGF-beta signaling pathway
KEGGPATH
hsa04390:Hippo signaling pathway
KEGGPATH
hsa04550:Signaling pathways regulating pluripotency of stem cells
KEGGPATH
hsa05200:Pathways in cancer
KEGGPATH
hsa05217:Basal cell carcinoma
WIKIPATH
WP1425:BMP Signalling and Regulation
目标的 KEGG 通路数据
| 标题 | 内容 |
|---|
| hsa04060 |
|
| hsa04340 |
|
| hsa04350 |
|
| hsa04390 |
|
| hsa04550 |
|
| hsa05200 |
|
| hsa05217 |
|
目标的 Wiki 路径数据
| 标题 | 内容 |
|---|
| WP615 |
|
| WP2895 |
|
| WP2760 |
|
| WP2666 |
|
| WP2380 |
|
| WP236 |
|
| WP1591 |
|
| WP1425 |
|
目标的蛋白质ID
| 标题 | 内容 |
|---|
| TARGETID |
|
| UNIPROID |
|
| TARGNAME |
|
| TARGTYPE |
|
目标的序列数据
| 标题 | 内容 |
|---|
| Bone morphogenetic protein 2 (BMP2) |
|