靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T67162

FORMERID

TTDS00012

UNIPROID

DRD2_HUMAN

TARGNAME

Dopamine D2 receptor (D2R)

GENENAME

DRD2

TARGTYPE

Successful target

SYNONYMS

Dopamine receptor 2; D(2) dopamine receptor

FUNCTION

Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase.

PDBSTRUC

6CM4; 5AER; 1I15

BIOCLASS

GPCR rhodopsin

SEQUENCE

MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC

DRUGINFO

Acetophenazine

DRUGINFO

Amisulpride

DRUGINFO

Aniracetam

DRUGINFO

Apomorphine

DRUGINFO

Aripiprazole

DRUGINFO

Bevantolol

DRUGINFO

Bromocriptine

DRUGINFO

Cabergoline

DRUGINFO

Cariprazine

目标的 KEGG 通路数据

标题	内容
hsa04015	Rap1 signaling pathway
hsa04024	cAMP signaling pathway
hsa04080	Neuroactive ligand-receptor interaction
hsa04540	Gap junction
hsa04728	Dopaminergic synapse
hsa05012	Parkinson's disease
hsa05030	Cocaine addiction
hsa05034	Alcoholism

目标的 Wiki 路径数据

标题	内容
WP666	Hypothetical Network for Drug Addiction
WP58	Monoamine GPCRs
WP455	GPCRs, Class A Rhodopsin-like
WP2636	Genes and (Common) Pathways Underlying Drug Addiction
WP1825	GPCR ligand binding
WP1824	GPCR downstream signaling
WP1602	Nicotine Activity on Dopaminergic Neurons

目标的蛋白质ID

标题	内容
TARGETID	T67162
UNIPROID	DRD2_HUMAN
TARGNAME	Dopamine D2 receptor (D2R)
TARGTYPE	Successful target

目标的序列数据

标题	内容
Dopamine D2 receptor (D2R)	MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC

标题

内容

Dopamine D2 receptor (D2R)

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