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靶点信息35(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Cathepsin D (CTSD)
TARGTYPE
Clinical trial target
FUNCTION
Plays a role in APP processing following cleavage and activation by ADAM30 which leads to APP degradation. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. Acid protease active in intracellular protein breakdown.
PDBSTRUC
4OD9; 4OC6; 4OBZ; 1LYW; 1LYB
SEQUENCE
MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL
DRUGINFO
1h-Benoximidazole-2-Carboxylic Acid
DRUGINFO
Carbocyclic Peptidomimetic
目标的 KEGG 通路数据
| 标题 | 内容 |
|---|
| hsa04071 |
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| hsa04142 |
|
| hsa05152 |
|
目标的蛋白质ID
| 标题 | 内容 |
|---|
| TARGETID |
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| UNIPROID |
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| TARGNAME |
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| TARGTYPE |
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