靶点信息17(本栏目收费,不能显示细节,电话13136136841)
靶点信息
标题
内容
相关药物
状态
TARGETID
T65291
FORMERID
TTDS00053
UNIPROID
AL3A2_HUMAN
TARGNAME
Fatty aldehyde dehydrogenase (ALDH3A2)
GENENAME
ALDH3A2
TARGTYPE
Successful target
SYNONYMS
Microsomal aldehyde dehydrogenase; Aldehyde dehydrogenase family 3 member A2; Aldehyde dehydrogenase 10; ALDH10
FUNCTION
Catalyzes the oxidation of medium and long chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid.
PDBSTRUC
4QGK
BIOCLASS
Aldehyde/oxo donor oxidoreductase
ECNUMBER
EC 1.2.1.3
SEQUENCE
MELEVRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITVLGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAPDYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGGETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVFSHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRPCLLKSLKREGANKLRYPPNSQSKVDWGKFFLLKRFNKEKLGLLLLTFLGIVAAVLVKAEYY
DRUGINFO
Disulfiram
DRUGINFO
NPS 1776
DRUGINFO
Aloe-emodin
DRUGINFO
NSC-527035
DRUGINFO
S-methyl 4-methyl-4-morpholinopent-2-ynethioate
目标的 KEGG 通路数据
标题内容
目标的 Wiki 路径数据
标题内容
目标的蛋白质ID
标题内容
TARGETID
UNIPROID
TARGNAME
TARGTYPE
目标的序列数据
标题内容
Fatty aldehyde dehydrogenase (ALDH3A2)
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