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靶点信息106(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1)
TARGTYPE
Clinical trial target
SYNONYMS
HSD11B1; 11beta-HSD1A; 11HSD1; 11-beta-hydroxysteroid dehydrogenase 1; 11-beta-HSD1; 11-DH; 11 beta-hydroxysteroid dehydrogenase type 1
FUNCTION
Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7- ketocholesterol to 7-beta-hydroxycholesterol.
PDBSTRUC
5QII; 5PGY; 5PGX; 5PGW; 5PGV
BIOCLASS
Short-chain dehydrogenases reductase
SEQUENCE
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
目标的 KEGG 通路数据
| 标题 | 内容 |
|---|
| hsa00140 |
|
| hsa00980 |
|
| hsa01100 |
|
| hsa05204 |
|
目标的蛋白质ID
| 标题 | 内容 |
|---|
| TARGETID |
|
| UNIPROID |
|
| TARGNAME |
|
| TARGTYPE |
|
目标的序列数据
| 标题 | 内容 |
|---|
| Corticosteroid 11-beta-dehydrogenase 1 (HSD11B1) |
|