TARGETID

T62974

FORMERID

TTDC00034

UNIPROID

SSR4_HUMAN

TARGNAME

Somatostatin receptor type 4 (SSTR4)

GENENAME

SSTR4

TARGTYPE

Clinical trial target

SYNONYMS

SSTR4; SS4R

FUNCTION

Receptor for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. It is functionally coupled not only to inhibition of adenylate cyclase, but also to activation of both arachidonate release and mitogen-activated protein (MAP) kinase cascade. Mediates antiproliferative action of somatostatin in tumor cells.

BIOCLASS

GPCR rhodopsin

SEQUENCE

MSAPSTLPPGGEEGLGTAWPSAANASSAPAEAEEAVAGPGDARAAGMVAIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASSAALRHWPFGSVLCRAVLSVDGLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAIFADTRPARGGQAVACNLQWPHPAWSAVFVVYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRSEKKITRLVLMVVVVFVLCWMPFYVVQLLNLFVTSLDATVNHVSLILSYANSCANPILYGFLSDNFRRFFQRVLCLRCCLLEGAGGAEEEPLDYYATALKSKGGAGCMCPPLPCQQEALQPEPGRKRIPLTRTTTF

DRUGINFO

ODT-8

DRUGINFO

177Lu-DOTATATE

DRUGINFO

CNTX-0290

DRUGINFO

FR-121196

DRUGINFO

99mTc-MIP-1407

DRUGINFO

Ala11-SRIF-14-amide

DRUGINFO

Ala6-SRIF-14-amide

DRUGINFO

beta3-tetrapeptide

DRUGINFO

CGP 23996

DRUGINFO

Cytotoxin Peptide Conjugate