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靶点信息28(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Thyrotropin receptor (TSHR)
TARGTYPE
Successful target
SYNONYMS
Thyroid stimulating hormone receptor; TSHR; TSH-R; TSH receptor
FUNCTION
Receptor for thyrothropin. Plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Also acts as a receptor for thyrostimulin (gpa2+gpb5).
PDBSTRUC
3G04; 2XWT; 1XUM
SEQUENCE
MRPADLLQLVLLLDLPRDLGGMGCSSPPCECHQEEDFRVTCKDIQRIPSLPPSTQTLKLIETHLRTIPSHAFSNLPNISRIYVSIDVTLQQLESHSFYNLSKVTHIEIRNTRNLTYIDPDALKELPLLKFLGIFNTGLKMFPDLTKVYSTDIFFILEITDNPYMTSIPVNAFQGLCNETLTLKLYNNGFTSVQGYAFNGTKLDAVYLNKNKYLTVIDKDAFGGVYSGPSLLDVSQTSVTALPSKGLEHLKELIARNTWTLKKLPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGILESLMCNESSMQSLRQRKSVNALNSPLHQEYEENLGDSIVGYKEKSKFQDTHNNAHYYVFFEEQEDEIIGFGQELKNPQEETLQAFDSHYDYTICGDSEDMVCTPKSDEFNPCEDIMGYKFLRIVVWFVSLLALLGNVFVLLILLTSHYKLNVPRFLMCNLAFADFCMGMYLLLIASVDLYTHSEYYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHACAIMVGGWVCCFLLALLPLVGISSYAKVSICLPMDTETPLALAYIVFVLTLNIVAFVIVCCCYVKIYITVRNPQYNPGDKDTKIAKRMAVLIFTDFICMAPISFYALSAILNKPLITVSNSKILLVLFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGICKRQAQAYRGQRVPPKNSTDIQVQKVTHDMRQGLHNMEDVYELIENSHLTPKKQGQISEEYMQTVL
DRUGINFO
Thyrotropin Alfa
DRUGINFO
Recombinant TSH superagonists
KEGGPATH
hsa04024:cAMP signaling pathway
KEGGPATH
hsa04080:Neuroactive ligand-receptor interaction
KEGGPATH
hsa04918:Thyroid hormone synthesis
KEGGPATH
hsa05320:Autoimmune thyroid disease
WIKIPATH
WP1824:GPCR downstream signaling
WIKIPATH
WP1825:GPCR ligand binding
目标的 KEGG 通路数据
| 标题 | 内容 |
|---|
| hsa04024 |
|
| hsa04080 |
|
| hsa04918 |
|
| hsa05320 |
|
目标的 Wiki 路径数据
| 标题 | 内容 |
|---|
| WP24 |
|
| WP2032 |
|
| WP1981 |
|
| WP1825 |
|
| WP1824 |
|
目标的蛋白质ID
| 标题 | 内容 |
|---|
| TARGETID |
|
| UNIPROID |
|
| TARGNAME |
|
| TARGTYPE |
|
目标的序列数据
| 标题 | 内容 |
|---|
| Thyrotropin receptor (TSHR) |
|