靶点信息57(本栏目收费,不能显示细节,电话13136136841)
靶点信息
标题
内容
相关药物
状态
TARGETID
T59626
FORMERID
TTDC00129
UNIPROID
LT4R1_HUMAN
TARGNAME
Leukotriene B4 receptor 1 (LTB4R)
GENENAME
LTB4R
TARGTYPE
Clinical trial target
SYNONYMS
P2Y7; P2Y purinoceptor 7; P2RY7; Leukotriene B(4) receptor BLT1; LTB4-R1; LTB4-R 1; LTB4-R; GPR16; G-protein coupled receptor 16; Chemoattractant receptor-like 1; CMKRL1; BLTR; BLT1; BLT
FUNCTION
The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response. Receptor for extracellular ATP > UTP and ADP.
BIOCLASS
GPCR rhodopsin
SEQUENCE
MNTTSSAAPPSLGVEFISLLAIILLSVALAVGLPGNSFVVWSILKRMQKRSVTALMVLNLALADLAVLLTAPFFLHFLAQGTWSFGLAGCRLCHYVCGVSMYASVLLITAMSLDRSLAVARPFVSQKLRTKAMARRVLAGIWVLSFLLATPVLAYRTVVPWKTNMSLCFPRYPSEGHRAFHLIFEAVTGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILTFAAFWLPYHVVNLAEAGRALAGQAAGLGLVGKRLSLARNVLIALAFLSSSVNPVLYACAGGGLLRSAGVGFVAKLLEGTGSEASSTRRGGSLGQTARSGPAALEPGPSESLTASSPLKLNELN
DRUGINFO
Amelubant
DRUGINFO
LTB4
DRUGINFO
Biomed 101
DRUGINFO
CP-195543
DRUGINFO
LY-223982
DRUGINFO
LY293111
DRUGINFO
SB-201993
DRUGINFO
CP-105696
目标的 KEGG 通路数据
标题内容
hsa04080
目标的 Wiki 路径数据
标题内容
WP80
WP455
WP2664
WP2431
WP1825
WP1824
目标的蛋白质ID
标题内容
TARGETID
UNIPROID
TARGNAME
TARGTYPE
目标的序列数据
标题内容
Leukotriene B4 receptor 1 (LTB4R)
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