TARGETID

T59045

FORMERID

TTDS00024

UNIPROID

GABT_HUMAN

TARGNAME

GABA transaminase (ABAT)

GENENAME

ABAT

TARGTYPE

Successful target

SYNONYMS

L-AIBAT; Gamma-amino-N-butyrate transaminase; GABA-T; GABA-AT; GABA aminotransferase; ABAT; (S)-3-amino-2-methylpropionate transaminase

FUNCTION

Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate andbeta-alanine.

BIOCLASS

Transaminase

ECNUMBER

EC 2.6.1.19

SEQUENCE

MASMLLAQRLACSFQHSYRLLVPGSRHISQAAAKVDVEFDYDGPLMKTEVPGPRSQELMKQLNIIQNAEAVHFFCNYEESRGNYLVDVDGNRMLDLYSQISSVPIGYSHPALLKLIQQPQNASMFVNRPALGILPPENFVEKLRQSLLSVAPKGMSQLITMACGSCSNENALKTIFMWYRSKERGQRGFSQEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDIARKHGCAFLVDEVQTGGGCTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHKEEFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLNNAAHAGKALLTGLLDLQARYPQFISRVRGRGTFCSFDTPDDSIRNKLILIARNKGVVLGGCGDKSIRFRPTLVFRDHHAHLFLNIFSDILADFK

DRUGINFO

Divalproex sodium

DRUGINFO

L-Alanine

DRUGINFO

Pyridoxal Phosphate

DRUGINFO

Pyruvic acid

DRUGINFO

Vigabatrin

DRUGINFO

CPP-115

DRUGINFO

K-828-AB

DRUGINFO

CPP -15

DRUGINFO

4-hydroxybenzaldehyde