TARGETID

T58992

FORMERID

TTDS00128

UNIPROID

OPRD_HUMAN

TARGNAME

Opioid receptor delta (OPRD1)

GENENAME

OPRD1

TARGTYPE

Successful target

SYNONYMS

OPRD; Delta-type opioid receptor; Delta opioid receptor; DOR-1; D-OR-1

FUNCTION

Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine. G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids.

PDBSTRUC

4RWD; 4RWA; 4N6H; 2IQM; 1OZC

BIOCLASS

GPCR rhodopsin

SEQUENCE

MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA

DRUGINFO

Butorphanol

DRUGINFO

Codeine

DRUGINFO

Eluxadoline

DRUGINFO

Hydromorphone

DRUGINFO

Loperamide

DRUGINFO

Oxycodone

DRUGINFO

ADL-5747

DRUGINFO

ADL-5859

DRUGINFO

AZD-2327