TARGETID

T58921

FORMERID

TTDS00338

UNIPROID

PPARG_HUMAN

TARGNAME

Peroxisome proliferator-activated receptor gamma (PPAR-gamma)

GENENAME

PPARG

TARGTYPE

Successful target

SYNONYMS

PPAR-gamma; Nuclear receptor subfamily 1 group C member 3; NR1C3

FUNCTION

Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (By similarity).

PDBSTRUC

6MD4; 6MD2; 6MD1; 6MD0; 6MCZ

BIOCLASS

Nuclear hormone receptor

SEQUENCE

MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY

DRUGINFO

Lobeglitazone

DRUGINFO

Pioglitazone

DRUGINFO

Rosiglitazone XR

DRUGINFO

Thiazolidinedione

DRUGINFO

Troglitazone

DRUGINFO

Glitazone

DRUGINFO

Balaglitazone

DRUGINFO

CS-038

DRUGINFO

FARGLITAZAR