靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T57943

FORMERID

TTDR00440

UNIPROID

CASP3_HUMAN

TARGNAME

Caspase-3 (CASP3)

GENENAME

CASP3

TARGTYPE

Clinical trial target

SYNONYMS

Yama protein; SREBP cleavage activity 1; SCA-1; Protein Yama; Cysteine protease CPP32; Caspase 3; CPP32; CPP-32; CASP-3; Apopain

FUNCTION

At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage. Involved in the activation cascade of caspases responsible for apoptosis execution.

BIOCLASS

Peptidase

ECNUMBER

EC 3.4.22.56

SEQUENCE

MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH

DRUGINFO

D01YIF

PAC1

Phase 1

DRUGINFO

D0L3PO

2-(4-fluoro-benzyl)isoquinoline-1,3,4-trione

Investigative

DRUGINFO

D09GKA

2-(4-methoxy-benzyl)isoquinoline-1,3,4-trione

Investigative

DRUGINFO

D0B8HU

2-allylisoquinoline-1,3,4-trione

Investigative

DRUGINFO

D09AED

2-benzylisoquinoline-1,3,4-trione

Investigative

DRUGINFO

D0FZ7W

2-methylisoquinoline-1,3,4-trione

Investigative

DRUGINFO

D05GGE

2-phenethylisoquinoline-1,3,4-trione

Investigative

DRUGINFO

D0D4RW

5-(azepan-1-ylsulfonyl)indoline-2,3-dione

Investigative

DRUGINFO

D0B6VI

5-(azetidin-1-ylsulfonyl)indoline-2,3-dione

Investigative

目标的 KEGG 通路数据

标题	内容
hsa04010	MAPK signaling pathway
hsa04115	p53 signaling pathway
hsa04210	Apoptosis
hsa04650	Natural killer cell mediated cytotoxicity
hsa04668	TNF signaling pathway
hsa04726	Serotonergic synapse
hsa04932	Non-alcoholic fatty liver disease (NAFLD)
hsa05010	Alzheimer's disease
hsa05012	Parkinson's disease
hsa05014	Amyotrophic lateral sclerosis (ALS)
hsa05016	Huntington's disease
hsa05120	Epithelial cell signaling in Helicobacter pylori infection
hsa05133	Pertussis
hsa05134	Legionellosis
hsa05145	Toxoplasmosis
hsa05146	Amoebiasis
hsa05152	Tuberculosis
hsa05161	Hepatitis B
hsa05168	Herpes simplex infection
hsa05200	Pathways in cancer
hsa05203	Viral carcinogenesis
hsa05205	Proteoglycans in cancer
hsa05206	MicroRNAs in cancer
hsa05210	Colorectal cancer
hsa05416	Viral myocarditis

目标的 Wiki 路径数据

标题	内容
WP707	DNA Damage Response
WP706	SIDS Susceptibility Pathways
WP384	Apoptosis Modulation by HSP70
WP382	MAPK Signaling Pathway
WP3286	Copper homeostasis
WP314	FAS pathway and Stress induction of HSP regulation
WP2714	Signaling by Hippo
WP254	Apoptosis
WP2447	Amyotrophic lateral sclerosis (ALS)
WP2431	Spinal Cord Injury
WP2380	BDNF signaling pathway
WP2377	Integrated Pancreatic Cancer Pathway
WP2374	Oncostatin M Signaling Pathway
WP2371	Parkinsons Disease Pathway
WP2355	Corticotropin-releasing hormone
WP2328	Allograft Rejection
WP2324	AGE/RAGE pathway
WP231	TNF alpha Signaling Pathway
WP2263	Prostate Cancer
WP2059	Alzheimers Disease
WP2036	TWEAK Signaling Pathway
WP1984	Integrated Breast Cancer Pathway
WP1976	Signalling by NGF
WP1971	Integrated Cancer pathway
WP1896	Regulation of Apoptosis
WP1841	Intrinsic Pathway for Apoptosis
WP1784	Apoptotic execution phase
WP1772	Apoptosis Modulation and Signaling
WP1530	miRNA Regulation of DNA Damage Response

目标的蛋白质ID

标题	内容
TARGETID	T57943
UNIPROID	CASP3_HUMAN
TARGNAME	Caspase-3 (CASP3)
TARGTYPE	Clinical Trial target

目标的序列数据

标题	内容
Caspase-3 (CASP3)	MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH

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