靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

REACPATH

R-HSA-198753:ERK/MAPK targets

REACPATH

R-HSA-2151209:Activation of PPARGC1A (PGC-1alpha) by phosphorylation

REACPATH

R-HSA-2559580:Oxidative Stress Induced Senescence

REACPATH

R-HSA-375170:CDO in myogenesis

REACPATH

R-HSA-376172:DSCAM interactions

REACPATH

R-HSA-4420097:VEGFA-VEGFR2 Pathway

REACPATH

R-HSA-450302:activated TAK1 mediates p38 MAPK activation

REACPATH

R-HSA-450341:Activation of the AP-1 family of transcription factors

REACPATH

R-HSA-450604:KSRP (KHSRP) binds and destabilizes mRNA

INTEPATH

atf2_pathway:ATF-2 transcription factor network

INTEPATH

cd40_pathway:CD40/CD40L signaling

INTEPATH

cxcr3pathway:CXCR3-mediated signaling events

INTEPATH

er_nongenomic_pathway:Plasma membrane estrogen receptor signaling

INTEPATH

faspathway:FAS (CD95) signaling pathway

INTEPATH

il2_1pathway:IL2-mediated signaling events

INTEPATH

il6_7pathway:IL6-mediated signaling events

INTEPATH

lymphangiogenesis_pathway:VEGFR3 signaling in lymphatic endothelium

INTEPATH

p38_mk2pathway:p38 signaling mediated by MAPKAP kinases

INTEPATH

p38_mkk3_6pathway:p38 MAPK signaling pathway

INTEPATH

p38alphabetadownstreampathway:Signaling mediated by p38-alpha and p38-beta

目标的 KEGG 通路数据

标题	内容
hsa04010	MAPK signaling pathway
hsa04015	Rap1 signaling pathway
hsa04068	FoxO signaling pathway
hsa04071	Sphingolipid signaling pathway
hsa04261	Adrenergic signaling in cardiomyocytes
hsa04370	VEGF signaling pathway
hsa04380	Osteoclast differentiation
hsa04550	Signaling pathways regulating pluripotency of stem cells
hsa04611	Platelet activation
hsa04620	Toll-like receptor signaling pathway
hsa04621	NOD-like receptor signaling pathway
hsa04622	RIG-I-like receptor signaling pathway
hsa04660	T cell receptor signaling pathway
hsa04664	Fc epsilon RI signaling pathway
hsa04668	TNF signaling pathway
hsa04670	Leukocyte transendothelial migration
hsa04722	Neurotrophin signaling pathway
hsa04723	Retrograde endocannabinoid signaling
hsa04728	Dopaminergic synapse
hsa04750	Inflammatory mediator regulation of TRP channels
hsa04912	GnRH signaling pathway
hsa04914	Progesterone-mediated oocyte maturation
hsa04917	Prolactin signaling pathway
hsa05014	Amyotrophic lateral sclerosis (ALS)
hsa05120	Epithelial cell signaling in Helicobacter pylori infection
hsa05131	Shigellosis
hsa05132	Salmonella infection
hsa05133	Pertussis
hsa05140	Leishmaniasis
hsa05142	Chagas disease (American trypanosomiasis)
hsa05145	Toxoplasmosis
hsa05152	Tuberculosis
hsa05160	Hepatitis C
hsa05164	Influenza A
hsa05169	Epstein-Barr virus infection
hsa05205	Proteoglycans in cancer

目标的 Wiki 路径数据

标题	内容
WP395	IL-4 Signaling Pathway
WP2792	MAP kinase activation in TLR cascade
WP2733	Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
WP2643	Nanoparticle-mediated activation of receptor signaling
WP2637	Structural Pathway of Interleukin 1 (IL-1)
WP2371	Parkinsons Disease Pathway
WP1873	NGF signalling via TRKA from the plasma membrane
WP1865	Myogenesis
WP1808	DSCAM interactions
WP1528	Physiological and Pathological Hypertrophy of the Heart
WP1449	Regulation of toll-like receptor signaling pathway
WP75	Toll-like receptor signaling pathway
WP481	Insulin Signaling

目标的蛋白质ID

标题	内容
TARGETID	T55729
UNIPROID	MK11_HUMAN
TARGNAME	Stress-activated protein kinase 2b (p38 beta)
TARGTYPE	Clinical Trial target

目标的序列数据

标题	内容
Stress-activated protein kinase 2b (p38 beta)	MSGPRAGFYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARRTYRELRLLKHLKHENVIGLLDVFTPATSIEDFSEVYLVTTLMGADLNNIVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLQGKALFPGSDYIDQLKRIMEVVGTPSPEVLAKISSEHARTYIQSLPPMPQKDLSSIFRGANPLAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDEPEAEPYDESVEAKERTLEEWKELTYQEVLSFKPPEPPKPPGSLEIEQ

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