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靶点信息20(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Choline kinase (CHKA)
TARGTYPE
Clinical trial target
SYNONYMS
ChoK; CHKA; CHETK-alpha
FUNCTION
Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline.
PDBSTRUC
5W6O; 5FUT; 5FTG; 5EQY; 5EQP
SEQUENCE
MKTKFCTGGEAEPSPLGLLLSCGSGSAAPAPGVGQQRDAASDLESKQLGGQQPPLALPPPPPLPLPLPLPQPPPPQPPADEQPEPRTRRRAYLWCKEFLPGAWRGLREDEFHISVIRGGLSNMLFQCSLPDTTATLGDEPRKVLLRLYGAILQMRSCNKEGSEQAQKENEFQGAEAMVLESVMFAILAERSLGPKLYGIFPQGRLEQFIPSRRLDTEELSLPDISAEIAEKMATFHGMKMPFNKEPKWLFGTMEKYLKEVLRIKFTEESRIKKLHKLLSYNLPLELENLRSLLESTPSPVVFCHNDCQEGNILLLEGRENSEKQKLMLIDFEYSSYNYRGFDIGNHFCEWMYDYSYEKYPFFRANIRKYPTKKQQLHFISSYLPAFQNDFENLSTEEKSIIKEEMLLEVNRFALASHFLWGLWSIVQAKISSIEFGYMDYAQARFDAYFHQKRKLGV
KEGGPATH
hsa00564:Glycerophospholipid metabolism
KEGGPATH
hsa01100:Metabolic pathways
KEGGPATH
hsa05231:Choline metabolism in cancer
WIKIPATH
WP2740:Glycerophospholipid biosynthesis
WIKIPATH
WP528:Acetylcholine Synthesis
WHIZPATH
PW000048:Phospholipid Biosynthesis
BIOCPATH
PWY3O-450:Phosphatidylcholine biosynthesis
目标的 KEGG 通路数据
| 标题 | 内容 |
|---|
| hsa00564 |
|
| hsa01100 |
|
| hsa05231 |
|
目标的蛋白质ID
| 标题 | 内容 |
|---|
| TARGETID |
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| UNIPROID |
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| TARGNAME |
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| TARGTYPE |
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目标的序列数据
| 标题 | 内容 |
|---|
| Choline kinase (CHKA) |
|