TARGETID

T54761

FORMERID

TTDI02324

UNIPROID

MBP_HUMAN

TARGNAME

Myelin basic protein (MBP)

GENENAME

MBP

TARGTYPE

Clinical trial target

SYNONYMS

Myelin membrane encephalitogenic protein; Myelin A1 protein

FUNCTION

The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.

PDBSTRUC

1ZGL; 1YMM; 1QCL; 1K2D; 1HQR

SEQUENCE

MGNHAGKRELNAEKASTNSETNRGESEKKRNLGELSRTTSEDNEVFGEADANQNNGTSSQDTAVTDSKRTADPKNAWQDAHPADPGSRPHLIRLFSRDAPGREDNTFKDRPSESDELQTIQEDSAATSESLDVMASQKRPSQRHGSKYLATASTMDHARHGFLPRHRDTGILDSIGRFFGGDRGAPKRGSGKDSHHPARTAHYGSLPQKSHGRTQDENPVVHFFKNIVTPRTPPPSQGKGRGLSLSRFSWGAEGQRPGFGYGGRASDYKSAHKGFKGVDAQGTLSKIFKLGGRDSRSGSPMARR

DRUGINFO

BHT-3009

DRUGINFO

NBI-5788

WIKIPATH

WP2064:Neural Crest Differentiation

WIKIPATH

WP2276:Glial Cell Differentiation

WIKIPATH

WP2431:Spinal Cord Injury

WIKIPATH

WP2637:Structural Pathway of Interleukin 1 (IL-1)

WIKIPATH

WP422:MAPK Cascade