靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T53381

FORMERID

TTDS00030

UNIPROID

ADA1D_HUMAN

TARGNAME

Adrenergic receptor alpha-1D (ADRA1D)

GENENAME

ADRA1D

TARGTYPE

Successful target

SYNONYMS

Alpha-adrenergic receptor 1a; Alpha-1D adrenoreceptor; Alpha-1D adrenoceptor; Alpha-1D adrenergic receptor; Alpha adrenergic receptor 1a; Alpha 1D-adrenoreceptor; Alpha 1D-adrenoceptor; ADRA1A

FUNCTION

This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium.

BIOCLASS

GPCR rhodopsin

SEQUENCE

MTFRDLLSVSFEGPRPDSSAGGSSAGGGGGSAGGAAPSEGPAVGGVPGGAGGGGGVVGAGSGEDNRSSAGEPGSAGAGGDVNGTAAVGGLVVSAQGVGVGVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWVVALVVSVGPLLGWKEPVPPDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGVKRERGKASEVVLRIHCRGAATGADGAHGMRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRRRPLWRVYGHHWRASTSGLRQDCAPSSGDAPPGAPLALTALPDPDPEPPGTPEMQAPVASRRKPPSAFREWRLLGPFRRPTTQLRAKVSSLSHKIRAGGAQRAEAACAQRSEVEAVSLGVPHEVAEGATCQAYELADYSNLRETDI

DRUGINFO

Alfuzosin

DRUGINFO

Armodafinil

DRUGINFO

Bunazosin

DRUGINFO

Doxazosin

DRUGINFO

Moxisylyte

DRUGINFO

Terazosin

DRUGINFO

Trimazosin

DRUGINFO

MEDETOMIDINE

DRUGINFO

DL-017

DRUGINFO

PMID30124346-Compound-LDT66

Patented

目标的 KEGG 通路数据

标题	内容
hsa04020	Calcium signaling pathway
hsa04022	cGMP-PKG signaling pathway
hsa04080	Neuroactive ligand-receptor interaction
hsa04261	Adrenergic signaling in cardiomyocytes
hsa04270	Vascular smooth muscle contraction
hsa04970	Salivary secretion

目标的 Wiki 路径数据

标题	内容
WP58	Monoamine GPCRs
WP536	Calcium Regulation in the Cardiac Cell
WP455	GPCRs, Class A Rhodopsin-like
WP2664	Gastrin-CREB signalling pathway via PKC and MAPK
WP1825	GPCR ligand binding
WP1824	GPCR downstream signaling
WP117	GPCRs, Other

目标的蛋白质ID

标题	内容
TARGETID	T53381
UNIPROID	ADA1D_HUMAN
TARGNAME	Adrenergic receptor alpha-1D (ADRA1D)
TARGTYPE	Successful target

目标的序列数据

标题	内容
Adrenergic receptor alpha-1D (ADRA1D)	MTFRDLLSVSFEGPRPDSSAGGSSAGGGGGSAGGAAPSEGPAVGGVPGGAGGGGGVVGAGSGEDNRSSAGEPGSAGAGGDVNGTAAVGGLVVSAQGVGVGVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWVVALVVSVGPLLGWKEPVPPDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGVKRERGKASEVVLRIHCRGAATGADGAHGMRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRRRPLWRVYGHHWRASTSGLRQDCAPSSGDAPPGAPLALTALPDPDPEPPGTPEMQAPVASRRKPPSAFREWRLLGPFRRPTTQLRAKVSSLSHKIRAGGAQRAEAACAQRSEVEAVSLGVPHEVAEGATCQAYELADYSNLRETDI

标题

内容

Adrenergic receptor alpha-1D (ADRA1D)

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