靶点信息_药药网

靶点信息

标题

内容

相关药物

状态

TARGETID

T53378

FORMERID

TTDR00209

UNIPROID

CAH4_HUMAN

TARGNAME

Carbonic anhydrase IV (CA-IV)

GENENAME

CA4

TARGTYPE

Successful target

SYNONYMS

Carbonic anhydrase 4; Carbonate dehydratase IV; CAIV

FUNCTION

May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid. Reversible hydration of carbon dioxide.

PDBSTRUC

5KU6; 5JNC; 5JNA; 5JN9; 5JN8

BIOCLASS

Alpha-carbonic anhydrase

ECNUMBER

EC 4.2.1.1

SEQUENCE

MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR

DRUGINFO

Brinzolamide

DRUGINFO

Salicyclic acid

DRUGINFO

Sulfamylon

DRUGINFO

Curcumin

DRUGINFO

PARABEN

DRUGINFO

PHENOL

DRUGINFO

Coumate

DRUGINFO

Sodium pyruvate

目标的 KEGG 通路数据

标题	内容
hsa00910	Nitrogen metabolism
hsa04964	Proximal tubule bicarbonate reclamation

目标的 Wiki 路径数据

标题	内容
WP2770	Reversible Hydration of Carbon Dioxide
WP2744	Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
WP2681	Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes

目标的蛋白质ID

标题	内容
TARGETID	T53378
UNIPROID	CAH4_HUMAN
TARGNAME	Carbonic anhydrase IV (CA-IV)
TARGTYPE	Successful target

目标的序列数据

标题	内容
Carbonic anhydrase IV (CA-IV)	MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR

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