TARGETID

T53024

FORMERID

TTDS00394

UNIPROID

SSR2_HUMAN

TARGNAME

Somatostatin receptor type 2 (SSTR2)

GENENAME

SSTR2

TARGTYPE

Successful target

SYNONYMS

Sst(2); Somatostatin receptor 2; SS2R; SS2-R; SS-2-R; SRIF-1

FUNCTION

Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization.

BIOCLASS

GPCR rhodopsin

SEQUENCE

MDMADEPLNGSHTWLSIPFDLNGSVVSTNTSNQTEPYYDLTSNAVLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGTDDGERSDSKQDKSRLNETTETQRTLLNGDLQTSI

DRUGINFO

Copper dotatate Cu-64

DRUGINFO

Ga-68-DOTATOC

DRUGINFO

Lanreotide acetate

DRUGINFO

Octreotide

DRUGINFO

Pasireotide

DRUGINFO

ODT-8

DRUGINFO

TBR-760

DRUGINFO

PEN-221

DRUGINFO

Re-188-P-2045

DRUGINFO

FR-121196