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靶点信息14(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Agouti-related protein (AGRP)
TARGTYPE
Clinical trial target
SYNONYMS
Agouti-related peptide; Agouti related protein; AGRP
FUNCTION
Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R. Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner.
PDBSTRUC
2IQV; 1MR0; 1HYK
SEQUENCE
MLTAAVLSCALLLALPATRGAQMGLAPMEGIRRPDQALLPELPGLGLRAPLKKTTAEQAEEDLLQEAQALAEVLDLQDREPRSSRRCVRLHESCLGQQVPCCDPCATCYCRFFNAFCYCRKLGTAMNPCSRT
KEGGPATH
hsa04920:Adipocytokine signaling pathway
INTEPATH
syndecan_3_pathway:Syndecan-3-mediated signaling events
目标的蛋白质ID
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目标的序列数据
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| Agouti-related protein (AGRP) |
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