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靶点信息17(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Melanoma-associated antigen 3 (MAGEA3)
TARGTYPE
Clinical trial target
SYNONYMS
Melanoma associated antigen-A3; Melanoma antigen 3; MAGE3; MAGE-A3 antigen; MAGE-A3; MAGE-3 antigen; Cancer/testis antigen 1.3; CT1.3; Antigen MZ2-D
FUNCTION
May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases.
PDBSTRUC
5BRZ; 4V0P; 1QEW
BIOCLASS
Melanoma associated antigen
SEQUENCE
MPLEQRSQHCKPEEGLEARGEALGLVGAQAPATEEQEAASSSSTLVEVTLGEVPAAESPDPPQSPQGASSLPTTMNYPLWSQSYEDSSNQEEEGPSTFPDLESEFQAALSRKVAELVHFLLLKYRAREPVTKAEMLGSVVGNWQYFFPVIFSKASSSLQLVFGIELMEVDPIGHLYIFATCLGLSYDGLLGDNQIMPKAGLLIIVLAIIAREGDCAPEEKIWEELSVLEVFEGREDSILGDPKKLLTQHFVQENYLEYRQVPGSDPACYEFLWGPRALVETSYVKVLHHMVKISGGPHISYPPLHEWVLREGEE
DRUGINFO
Melanoma vaccine (ALVAC)
目标的蛋白质ID
| 标题 | 内容 |
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| TARGETID |
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| UNIPROID |
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| TARGNAME |
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| TARGTYPE |
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目标的序列数据
| 标题 | 内容 |
|---|
| Melanoma-associated antigen 3 (MAGEA3) |
|