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靶点信息12(本栏目收费,不能显示细节,电话13136136841)
靶点信息
TARGNAME
Ganglioside GM2 activator (GM2A)
TARGTYPE
Clinical trial target
SYNONYMS
Sphingolipid activator protein 3; SAP3; Ganglioside GM2 activator isoform short; GM2AP; GM2A; Cerebroside sulfate activator protein
FUNCTION
The large binding pocket can accommodate severalsingle chain phospholipids and fatty acids, GM2A also exhibits some calcium-independent phospholipase activity. Binds gangliosides and stimulates ganglioside GM2 degradation. It stimulates only the breakdown of ganglioside GM2 and glycolipid GA2 by beta-hexosaminidase A. It extracts single GM2 molecules from membranes and presents them in soluble form to beta- hexosaminidase A forcleavage of N-acetyl-D-galactosamine and conversion to GM3.
PDBSTRUC
2AG9; 2AG4; 2AG2; 2AF9; 1TJJ
SEQUENCE
MQSLMQAPLLIALGLLLAAPAQAHLKKPSQLSSFSWDNCDEGKDPAVIRSLTLEPDPIIVPGNVTLSVMGSTSVPLSSPLKVDLVLEKEVAGLWIKIPCTDYIGSCTFEHFCDVLDMLIPTGEPCPEPLRTYGLPCHCPFKEGTYSLPKSEFVVPDLELPSWLTTGNYRIESVLSSSGKRLGCIKIAASLKGI
NET_PATH
NetPath_7:TGF_beta_Receptor Signaling Pathway
目标的蛋白质ID
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目标的序列数据
| 标题 | 内容 |
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| Ganglioside GM2 activator (GM2A) |
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